Anti-tumor application of tanshinone compound

Abstract

The invention relates to an application of a tanshinone compound in preparing anti-tumor medicaments, and the prepared medicaments can resist tumors, such as brain tumors, lung cancer, liver caner, breast cancer, prostatic cancer, pancreatic cancer, cervical cancer, gastric cancer, esophagus cancer, and the like. Proved by experiments, the tanshinone compound is concentration-dependent to suppress the proliferation of tumor cells. The compound can obviously induce the expression of quinone reductase and obviously suppress the generation of tumor vessels, thus the compound can also be used for preparing cancer chemical prevention medicaments, anti-inflammatory medicaments and medicaments for suppressing the generation of the tumor vessels. Frequently used low-price reagents, such as alcohol, chloroform, methanol, silica gel, and the like, are used for separating tanshinone compound monomers from medicinal materials. The method is simple and reliable, has low cost and high efficiency, can be used for carrying out industrialized mass production and is beneficial to popularization and application. The tanshinone compound has a structural general formula disclosed in the specification.

Description

technical field The invention belongs to the field of herbal medicinal ingredients and antitumor compounds, and particularly relates to the active ingredient tanshinone compound extracted from the traditional Chinese medicine Danshen (Salvia miltiorrhiza Bge.), which has obvious preventive and therapeutic effects on tumors, and its application. Background technique At present, millions of people die of cancer every year all over the world, and new cases are still increasing year by year. Among the 1.3 billion population in my country, millions of people die of cancer every year, and cancer has become the first cause of death. At present, chemotherapy and radiotherapy are the first choice for the treatment of cancer, but their specificity to tumor cells is poor, so they have relatively large toxic and side effects, and some tumor cells are not sensitive to chemotherapy and radiotherapy, thus limiting them to a large extent. application in clinic. In recent years, in order ...

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that Danshen extract has anti-tumor effects, among which the anti-non-small cell lung cancer and breast cancer effects of tanshinone IIA are mainly studied, and the anti-tumor effects of other tanshinone compounds are rarely reported

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