Oral and skin compositions

A composition and skin technology, applied in the field of oral and dermatological compositions, can solve problems such as formation of dental caries, easy acidity of the oral cavity, excessive grinding of teeth, etc., to prevent the occurrence of dental caries, improve cleaning effect, and prevent tooth wear and tear. Effect

Active Publication Date: 2010-08-11
株式会社日本高度医疗研究会 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a problem that, based on the characteristics of the abrasives added, brushing for a long time will excessively grind the teeth, causing the enamel to peel off, and instead it becomes easy to become caries
Furthermore, the present inventors have found that if the pH in the oral cavity is acidic, the enamel will dissolve and caries will easily occur (the pH at which the enamel starts to dissolve is about 5.5), but the pH of drinking water (pH 5 to 7) and food is absolutely Most of them are acidic, so there is a problem that an acidic environment tends to be formed in the mouth, and caries will form even if you brush your teeth

Method used

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  • Oral and skin compositions
  • Oral and skin compositions
  • Oral and skin compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The following shows experimental examples to specifically explain the present invention. However, the scope of the present invention is not limited to this.

[0056] In Example 1, according to the prescriptions shown in Table 1 and Table 2, the oral gel of the invention example was prepared by a conventional method, and periodontitis, stomatitis, and side effects were evaluated by the evaluation method shown below. In addition, according to the prescriptions shown in Table 3 and Table 4, the oral gel of the comparative example was prepared by a conventional method, and the same evaluation was performed. The amount used is expressed in mass %.

[0057] [Table 1]

[0058]

[0059] [Table 2]

[0060] Invention Examples

[0061] [table 3]

[0062] Comparative example

[0063] Comparative example

[0064] [Table 4]

[0065] Comparative example

[0066] Evaluation method

[0067] For each invention example and comparative example, 10 males and 10 females, totaling 20 subje...

Embodiment 2

[0084] In Example 2, the anti-dermatitis gel and anti-fungal gel of the invention example were prepared by conventional methods according to the prescriptions shown in Table 1 and Table 2, and the dermatitis, white ringworm, and side effects were evaluated by the evaluation method shown below . In addition, the anti-dermatitis gel and anti-fungal gel of the comparative example were prepared by conventional methods according to the prescriptions shown in the above-mentioned Table 3 and Table 4, and the same evaluation was performed. The amount used is expressed in mass %.

[0085] Evaluation method

[0086] For each inventive example and comparative example, 10 subjects in total, 5 males and 5 females, cleaned the affected area and its surroundings with cotton or the like, and applied 1 g of the composition to the affected area with fingers for 1 week. As a result of the experiment, the affected area was observed and the number of subjects was determined by the following classific...

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PUM

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Abstract

Disclosed is a skin or oral composition comprising an anti-bacterial agent, which produces no adverse side effect caused by a steroid contained therein. The composition comprises: 0.01 to 4.5 mass% of at least one component selected from the group consisting of an anti-bacterial agent, an anti-viral agent, an anti-HIV agent, a non-nucleoside reverse transcriptase inhibitor, an anti-cancer agent for external application, and a bactericidal agent; 0.01 to 4.5 mass% of a non-steroidal anti-inflammatory agent; 0.001 to 4.5 mass% of a steroidal anti-inflammatory agent; and 0.001 to 10 mass% of a super-water-absorbent polymer or a cellulose derivative.

Description

Technical field [0001] The present invention relates to a composition for oral cavity and skin. More specifically, it relates to a composition for skin and oral cavity containing at least one antibacterial agent, etc., the composition comprising in addition to a steroidal anti-inflammatory agent Non-steroidal anti-inflammatory agents have no side effects and are excellent in the treatment of periodontal diseases and dermatitis. Background technique [0002] It is known that steroids strongly inhibit inflammation by inhibiting the function of lymphocytes, or inhibiting inflammatory peptides, and inhibiting the proliferation of fibroblasts. Therefore, they are widely used in the treatment of inflammatory diseases, and are the treatment of periodontitis and stomatitis. The most powerful anti-inflammatory agent for oral diseases and dermatitis. In particular, corticosteroids are the most widely used anti-inflammatory drugs for both acute and chronic inflammation. [0003] However, st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K47/04A61K47/32A61K47/36A61K47/38A61P1/02A61P17/00A61P43/00
CPCA61K9/0063A61K47/02A61K45/06A61K47/38A61K9/0014A61K33/30A61K47/32A61P1/02A61P17/00A61P29/00A61P31/04A61P43/00A61K2300/00
Inventor 野田哲
Owner 株式会社日本高度医疗研究会
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