Application, preparation and preparation method of synthetic palmatine
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A technology of palmatine hydrochloride and preparation, which is applied in the fields of the use, preparation and preparation of palmatine synthesis, and can solve the problems of whether it can be replaced or equivalent without research, and has no research.
Inactive Publication Date: 2010-08-18
刘波澜 +1
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In addition, there is also a patent application for the synthesis of palmatine, the name of the invention: the preparation method of palmatine, the publication number: CN100999522A, this patent only discusses a simple synthesis method, and does no
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Embodiment 1
[0145] Embodiment 1. Preparation of glyoxal complex
[0146] Material ratio: Glacial acetic acid 900kg: copper sulfate 135kg: sodium chloride 100kg: glyoxal 30kg: N-(2,3-dimethoxy-N-benzyl)-β-(3,4-dimethoxy phenyl) ethylamine sulfate (or inorganic salts such as hydrochloride) 100kg
[0147] Weigh 900kg of glacial acetic acid, 135kg of copper chloride and 30kg of glyoxal, stir and mix them in the reaction kettle, heat up, and control the temperature at 70°C. After fully stirring for 45min, the aldehyde-copper complex is obtained.
Embodiment 2
[0148] Embodiment 2. Preparation of palmatine complex
[0149] Get glacial acetic acid 900kg, cupric chloride 135kg, embodiment 1. The aldehyde copper complex and N-(2,3-dimethoxy-N-benzyl)-β-(3,4-dimethoxy 100kg of phenyl)ethylamine hydrochloride was stirred and mixed in a reaction kettle, and the temperature was raised to control the temperature at 95°C. After stirring for 4 hours, the temperature was lowered, and the solvent was removed to obtain the palmatine complex.
Embodiment 3
[0150] Embodiment 3. Preparation of Palmatine
[0151] Take the palmatine complex compound of Example 2, add 1000kg of water, stir and mix, heat up to 90°C, add saturated sodium carbonate solution, adjust the pH value to 8.0, filter while it is hot, collect the filtrate, cool the filtrate, and crystallize. The crystal form is needle-like crystal or granular crystal, and the color is light yellow to dark yellow. After cooling down and filtering, 90kg of palmatine (molecular formula: C 21 h 21 NO 4 or C 21 h 21 NO 4 ·3H 2 O).
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Abstract
The invention discloses application and a preparation of synthetic palmatine (or inorganic salts, such as hydrochloride, sulfate, phosphate, and the like, and organic salts or derivatives) prepared by a chemical synthetic method, the preparation of raw materials and the fine preparation of raw materials. The synthetic palmatine are needle-like crystals or particle crystals of light yellow to dark yellow. Firstly proved by pharmacological and toxicological substitution research, the synthetic palmatine can be used as medicines instead of palmatine extracted from plants, has better effects than the palmatine extracted from plants in the curative effect aspects of resisting inflammation, bacteria, viruses, and the like, is synthesized by the disclosed methods or the method in the invention, can be prepared into injections, and like to be applied to clinical departments of resisting bacteria, eliminating inflammation and resisting inflection.
Description
technical field [0001] The present invention relates to the use, preparation, raw material preparation and raw material of palmatine (or its hydrochloride, sulfate, phosphate and other inorganic acid salts and organic acid salts, or derivatives) made by chemical synthesis Refined, the synthesis of palmatine in the present invention is light yellow to deep yellow needle-like crystals or granular crystals, in the field of medicine, as anti-inflammatory, antibacterial, antiviral drugs, used in various clinical departments, especially respiratory and gynecology , gastroenterology, dermatology, surgery, oncology and other internal medicine departments that require antibacterial, anti-inflammatory and anti-infective fields; as a metabolic medicine field, it is used in diabetes, hypertension, hyperlipidemia, etc.; it can also be used as a drug for enhancing immunity. This invention belongs to the innovative invention in the field of medicine. Background technique [0002] Palmatin...
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