Method for preparing water-soluble nanometer preparation by insoluble traditional Chinese medicine containing ring structures
A cyclic structure, nano-formulation technology, which is applied to medical preparations containing active ingredients, organic active ingredients, pharmaceutical formulations, etc., can solve problems such as no research reports on amphiphilic chitosan derivatives, and achieve simple process. , The effect of simple process and convenient operation
Inactive Publication Date: 2010-08-25
SUN YAT SEN UNIV
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But so far, there are no research reports on the use of such amphiphilic chitosan derivatives in water-soluble nano-Chinese medicine preparations.
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Abstract
The invention discloses a method for preparing a water-soluble nanometer preparation by insoluble traditional Chinese medicine containing ring structures. The water-soluble traditional Chinese medicine nanometer preparation is prepared by hydrophobic solubilization action of the insoluble traditional Chinese medicine containing the ring structures and amphiphilic chitosan derivatives containing bile acid hydrophobic groups. The preparation method has the advantages of simplicity, feasibility and easy popularization. The required equipment and raw materials have low cost and are easily obtained. The prepared water-soluble nanometer drug carrier has better biocompatibility, can perform the function of releasing the traditional Chinese medicine slowly, and can bring better social benefit and economic benefit.
Description
technical field The invention relates to a preparation method of a water-soluble nanometer traditional Chinese medicine preparation, specifically a kind of insoluble traditional Chinese medicine containing a ring structure and an amphiphilic chitosan derivative micelle containing a bile acid hydrophobic group through hydrophobic solubilization The preparation method for forming water-soluble drug-loaded nanoparticles can be widely used in traditional Chinese medicine pharmaceutical industry and other pharmaceutical industries. Background technique Traditional Chinese medicine is a treasure of our country's traditional culture. After thousands of years of practice, it has formed a complete theoretical system, and it still plays an extremely important role in my country's medical care. However, traditional Chinese medicines have problems such as outdated dosage forms, large doses, and poor stability. In particular, some insoluble Chinese medicines containing ring structures (a...
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IPC IPC(8): A61K9/00A61K47/36A61K36/00A61K31/7048A61K31/12A61K31/337A61K31/4745A61K31/352
Inventor 杨立群邓宇斌蓝育青王双萍郑海生周怀胜张黎明程良正
Owner SUN YAT SEN UNIV
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