Valsartan liposome, preparation method thereof and medicinal composition containing same

Abstract

The invention relates to valsartan liposome, a preparation method thereof and a medicinal composition containing the same. Active components of the medicinal composition are valsartan and/or amlodipine. The valsartan liposome consists of the valsartan or pharmaceutically acceptable salt thereof and phospholipid, wherein the weight of the phospholipid is 1 to 10 times that of the valsartan or the pharmaceutically acceptable salt thereof; and the medicinal composition prepared by the valsartan liposome not only meets the requirement of Chinese Pharmacopoeia, but also has the advantages of quicker dissolution, quicker drug effect exertion, obviously improved biological utilization compared with conventional valsartan medicinal composition.

Description

A kind of valsartan liposome, its preparation method and its pharmaceutical composition technical field The invention relates to a valsartan liposome, a preparation method thereof and a pharmaceutical composition containing it. The valsartan liposome has a faster dissolution rate and a faster drug effect than ordinary valsartan pharmaceutical compositions. 1. The advantages of significantly improved bioavailability belong to the technical field of medicine. Background technique Due to the development of social economy and the change of people's lifestyle, the prevalence of hypertension in our country shows a continuous growth trend. Hypertension is a common and frequently-occurring disease, and it is also the most important risk factor for cardiovascular and cerebrovascular diseases. There is a continuous positive correlation between blood pressure level and the incidence of cardiovascular disease. The important complications of hypertension, stroke, heart disease and ki...

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Problems solved by technology

The prepared liposome also has higher auxiliary material content and less main drug content; the external size of the pharma

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