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Experimental simulation method of pre-op site selection of coronary artery bypass graft anastomosis

A technology for coronary artery and experimental simulation, applied in surgery, teaching models, medical science, etc., to accelerate the proliferation of vascular tissue cells and avoid fluid competition

Inactive Publication Date: 2013-05-22
郭应强
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  • Description
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Problems solved by technology

[0002] Coronary artery bypass grafting is one of the effective ways to save the lives of patients with heart disease. Although Angioplasty and Stent have less surgical trauma, these two methods are generally only applicable to only one coronary artery. In the case of stenosis, for continuous multiple stenosis, arterial bypass surgery is still required to bypass the narrowed coronary artery

Method used

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  • Experimental simulation method of pre-op site selection of coronary artery bypass graft anastomosis
  • Experimental simulation method of pre-op site selection of coronary artery bypass graft anastomosis
  • Experimental simulation method of pre-op site selection of coronary artery bypass graft anastomosis

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Embodiment Construction

[0050] 1. Closed loop perfusion system

[0051] The closed-loop perfusion system includes a liquid storage tank 1 and a peristaltic pump 2 connected thereto, and also includes a buffer tank 3, a first valve 4, an anastomosis model 6, a second valve 5 and a pressure tank 8, and the side wall of the buffer tank 3 The upper part and the lower part are respectively provided with an overflow port, and the buffer tank 3 is connected to the peristaltic pump 2 through a pipeline, the overflow port at the upper end of the buffer tank 3 is connected to the liquid storage tank 1 through a pipeline, and the overflow port at the lower end is connected to the second tank through a pipeline in turn. A valve 4, an anastomosis model 6, a second valve 5 and a pressure tank 8, a pressure gauge 7 is also connected between the first valve 4 and the second valve 5, and the outlet pipe of the pressure tank 8 is connected to the storage tank through a pipeline. Liquid tank 1.

[0052] see figure 1 ...

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Abstract

The invention discloses an experimental simulation method of a pre-op site selection of coronary artery bypass graft anastomosis, comprising the following steps of: preparing the anastomotic models of different formations; cultivating human vessel histocyte obtained by separation in DMEM containing 10% fetal calf serum (GIBCO) in the atmosphere of 5% CO2 at 37 DEG C till fusing, then digesting toprepare cell suspension, cultivating the cells on a glass slide, placing the glass slide in a six-orifice plate for standing cultivation for 6 h for later use; fixing the glass slide carried with thecultivated vessel histocyte in an anastomotic opening area of the anastomotic model; connecting the whole anastomotic model to a closed-circuit perfusion system which is driven by a peristaltic pump,simulating blood flow of human body to perform dynamic loading experiment, taking out the cell glass slide to image with a fluorescence microscope, and scanning with an electron scanning microscope.

Description

technical field [0001] The invention relates to an experimental simulation method for site selection before coronary artery bypass graft anastomosis. Background technique [0002] Coronary artery bypass grafting is one of the effective ways to save the lives of patients with heart disease. Although Angioplasty and Stent have less surgical trauma, these two methods are generally only applicable to only one coronary artery. In the case of stenosis, for continuous multiple stenosis, arterial bypass surgery is still required to bypass the narrowed coronary artery. Over the past few years, a large number of arterial grafts have been implanted in heart patients to restore blood flow to diseased or damaged arteries. This procedure uses artificial or natural blood vessels to bypass severely narrowed (75% area reduction) arteries. In coronary artery bypass surgery, the patient's own venous blood vessel is generally used as a graft, and the front end of the graft is sutured to the a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B19/00G09B23/28A61B90/00
Inventor 郭应强杨刚吴江张本贵肖正华
Owner 郭应强
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