New furan derivative and application thereof

Abstract

The invention belongs to the technical field of medicaments and relates to a furan derivative and application thereof, in particular to a new furan derivative for treating immunologic diseases. The structural formula of the furan derivative is shown in the specifications, wherein an R group can be linear chain alkyl and branched chain alkyl having 2 to 11 carbon atoms. A compound has a stable structure and various clinically acceptable formulations can be prepared by matching the compound with an appropriate amount of pharmaceutical adjuvant. An immunology experimental result indicates that the compound has relatively high anti-complement activity and no activity difference between two formulations, so the compound has the advantages of relatively high activity, little medicament dosage and the like. The furan derivative and a preparation which is possibly developed by the furan derivative are mainly used for treating various diseases caused by over activation of a complement system. The R group is linear chain alkyl and branched chain alkyl having 2 to 11 carbon atoms.

Description

technical field The invention belongs to the technical field of medicine and relates to novel furan derivatives and applications thereof. In particular, it relates to novel furan derivatives and their use in medicines for treating various diseases caused by overactivation of the complement system. Background technique Abnormal activation of the complement system can cause an overreaction of the human immune system, resulting in damage to the body's own normal tissues. Diseases related to overactivation of complement include rheumatoid arthritis, senile dementia, systemic lupus erythematosus, ischemia-reperfusion, acute myocardial infarction, acute respiratory distress syndrome, etc. Currently, there is no high-efficiency, low-toxicity, specific complement inhibitor clinically. Immunosuppressants such as glucocorticoids, cyclophosphamide, and methotrexate, which are widely used clinically, have a certain therapeutic effect on diseases related to overactivation of complement...

AI Technical Summary

Problems solved by technology

Immunosuppressants such as glucocorticoids, cyclophosphamide, and methotrexate, which are widely used clinically, have a certain therapeutic effect on diseases related to overactivation of complement, but these drugs also have inhibitory effects on other immune systems, and their selectivity is poor. Reduce the body's defense function, resulting in a decline in the body's ability to resist infection, resulting in a variety of complications and side effects

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