Iguratimod crystal habit and composition thereof

A technology of crystal form and composition, which is applied in the field of autoimmune regulation drugs to achieve the effects of easy production and high biological activity
CN101885718BActive Publication Date: 2012-05-23TIANJIN INSTITUTE OF PHARMA RESEARCH +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2012-05-23

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Abstract

The invention relates to a crystal habit (iguratimod) of N-[3- (formamido)-4-oxygen-6-phenoxy-4H-1- benzopyran-7-base]-methylsulfonamid. In addition, the invention also relates to application of iguratimod crystal habit to medicine for treating rheumatoid arthritis, a medicine composition containing the iguratimod crystal habit and a preparation method of the iguratimod crystal habit.
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Description

technical field

[0001] The invention belongs to the technical field of autoimmune regulation medicines, and more specifically, the invention relates to the crystal form of iguratimod, its preparation method and its application in the preparation of pharmaceutical preparations. Background technique

[0002] Rheumatoid arthritis (RA) is a highly disabling systemic autoimmune disease. If it is not actively and effectively treated, joint erosions will generally occur within 1 to 2 years. Currently, RA treatment is divided into two categories of drugs, non-steroidal anti-inflammatory analgesics (NSAIDs) and disease-modifying antirheumatic drugs (DMARDs). The main function of NSAIDs is to relieve joint pain, swelling and improve joint function in RA patients, but it does not change the progress of the disease, nor prevent joint destruction, and its severe adverse reactions to the gastrointestinal tract limit its use. Compared with NSAIDs, DMARDs have a slower onset of action and ...

Claims

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