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Nuezhenoside and rhoifolin composition and use thereof in preparation of drugs

A technique for anacardoside and nucleoside, which is applied in the field of nucleoside and nucleoside compositions and their preparation and application fields, can solve problems such as undiscovered, achieves inhibition of replication, prevention and treatment of influenza and its complications, Infection reduction effect

Active Publication Date: 2010-12-01
JIANGXI SHANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been found that the round leaves of Shanxiang and its privet and rhodolin, Ligustrum lucidum and its privet, citrus red and its contained rhizoside have the effect of inhibiting influenza virus infection and replication. effect, and it was not found to have the effect of inhibiting neuraminidase

Method used

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  • Nuezhenoside and rhoifolin composition and use thereof in preparation of drugs
  • Nuezhenoside and rhoifolin composition and use thereof in preparation of drugs
  • Nuezhenoside and rhoifolin composition and use thereof in preparation of drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The molecular formula of the privetin provided by the present invention: C 33 h 40 o 18 , Molecular weight: 724.2, the structural formula of described privetin is as follows:

[0031]

[0032] Wherein the molecular formula of Rhodorin: C 27 h 30 o 14 , Molecular weight: 578.52, the structural formula of described Rhodorin is as follows:

[0033]

[0034] Take 100,000g of the leaves of Shanxiangyuan, add 12 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, add 10 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recover ethanol, and pass the aqueous solution through the The treated D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% privetin , the mixed total glucosides of rhodoside, separ...

Embodiment 2

[0037]Take Ligustrum lucidum 10000g, add 12 times the amount of 70% ethanol for reflux extraction for 2 hours, filter, add 10 times the amount of 70% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recycle the ethanol, and pass the aqueous solution through the The treated D101 macroporous resin column was eluted with water, 10% ethanol, 45% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 45% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% privetin The mixed total glycosides are separated by silica gel column chromatography and Sephadex LH-20 column chromatography, and the fractions of privetin are combined and crystallized to obtain pure privetin (184g, purity: 98.3%). Standard UV, IR, ESI-MS, 1 H-NMR, 13 Compared with C-NMR, the structure of privetin was determined.

Embodiment 3

[0039] Take 10000g of Ligustrum lucidum, add 10 times the amount of 65% ethanol for reflux extraction for 2 hours, filter, add 8 times the amount of 65% ethanol for reflux extraction for 1.5 hours, filter, combine the two extracts, recycle the ethanol, and pass the aqueous solution through the The treated D101 macroporous resin column was eluted with water, 8% ethanol, 40% ethanol, and 1% sodium hydroxide solution respectively, and the eluted part of 40% ethanol was collected, concentrated under reduced pressure, and dried to obtain more than 30% privetin The mixed total glycosides of the mixed glycosides are separated by silica gel column chromatography and Sephadex LH-20 column chromatography, and the fractions of privetin are merged and crystallized to obtain pure privetin (190g, purity: 98.5%). Standard UV, IR, ESI-MS, 1 H-NMR, 13 Compared with C-NMR, the structure of privetin was determined.

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Abstract

The invention relates to a nuezhenoside and rhoifolin composition, which is prepared by mixing 20%-80% by weight of nuezhenoside with 80%-20% by weight of rhoifolin, the composition can be used for preventing and treating influenza as a neuraminidase inhibitor and be prepared into pharmaceutically acceptable formulations.

Description

technical field [0001] The invention relates to a composition of privetin and rhoiferin and its use for preparing medicines. Background technique [0002] At present, influenza virus is becoming more and more serious, and influenza virus is closely related to respiratory diseases and systemic diseases caused by it. my country is one of the countries with high incidence of influenza. Not only has a large population, but also living habits are conducive to the transmission of influenza virus. The average number of episodes ranged from 0.3 to 0.7, and 2 to 4 in key groups. Influenza poses a serious threat to human beings, especially the emerging strains of influenza virus, which not only cause secondary infections of other microorganisms, but also directly lead to organ damage and allergic reactions leading to death. But there is no effective method and treatment means for treating influenza virus and its disease (influenza) at present, such as treating the inflammatory respons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/16A61P13/12A61P1/00A61P11/00C07H17/07C07H1/08
Inventor 杨小玲谢宁叶劲英王燕平李志勇吕武清刘地发程帆蔡永红
Owner JIANGXI SHANXIANG PHARMA
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