Cynanchum otophyllum aglycone and medical application of extractive containing same

A technology of extract and ginseng, applied in the field of medicine, can solve the problems of death, canine toxicity, dog poisoning, etc.

Active Publication Date: 2011-01-26
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Qingyang ginseng is non-toxic to humans under the dosage, but the feces eaten by humans and then eaten by dogs can cause poisoning or death to dogs...

Method used

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  • Cynanchum otophyllum aglycone and medical application of extractive containing same
  • Cynanchum otophyllum aglycone and medical application of extractive containing same
  • Cynanchum otophyllum aglycone and medical application of extractive containing same

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specific Embodiment approach

[0066] The present invention is further illustrated below through specific examples and experimental examples, but it should be understood that these examples and experimental examples are only used for more detailed description, and should not be interpreted as being used to limit the present invention in any form. invention.

[0067] The present invention provides general and / or specific descriptions of the materials and test methods used in the tests. While many of the materials and methods of manipulation which are employed for the purposes of the invention are well known in the art, the invention has been described here in as much detail as possible. It will be clear to those skilled in the art that in the following, unless otherwise specified, the materials and operation methods used in the present invention are well known in the art.

Embodiment 1

[0068] Embodiment 1: Extraction, separation and synthesis of Qingyangshen extract and Qingyangshen glycosides (glycosides) structural research

[0069] step 1: Take 1 kg of Qingyang ginseng (Cynanchum otopyllum Schneid, produced by Qingyang ginseng planting factory in Yuncheng, Shanxi, identified by Professor Wang Tiancai of the factory), reflux extraction with 95% ethanol for 3 times, concentrate under reduced pressure to obtain extract, and use ethyl acetate / water solution (1 / 1, v / v) extraction, the ethyl acetate layer was decompressed, concentrated to obtain the extract, and dried to obtain 9.6g, which is the extract of Qingyangshen. It has been determined that the content of qingyangshenside (glucoside) in the extract is about 5% (w / w).

[0070] Step 2: Take 5 g of the Qingyang ginseng extract obtained in step 1, go through silica gel (100-200 mesh) column chromatography (column bed: Φ=50mm, H=700mm, V=500ml), and elute with chloroform / methanol gradient; Column chr...

Embodiment 2

[0072] Example 2: Preparation of Qingyangshen Extract Tablets and Qingyangshen Glycosides (Glycosides) Yuan Tablets

[0073] According to the formula ratio in the following table 1 and table 2, get the raw material drug (respectively obtained from the Qingyang ginseng extract and Qingyang ginseng (glycoside) element of embodiment 1) and dissolve in 50% ethanol, add starch, mix, and then Add gum arabic and carboxymethyl cellulose and mix thoroughly to make a soft material, wet granulate, and dry at 60°C. Whole grains, added magnesium stearate and compressed into tablets, ready to be obtained. The obtained Qingyangshen extract tablet and Qingyangshen glycoside (glycoside) element tablet are both white smooth and hard tablets.

[0074] Table 1. Formula for preparing 100 tablets of Qingyang ginseng extract

[0075] components

[0076] Table 2. Formula for preparing 100 tablets of Qingyang ginsenoside (glycoside) element

[0077] components

[0078] ...

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Abstract

The invention relates to cynanchum otophyllum aglycone and medical application of an extractive containing the same, in particular to a cynanchum otophyllum extract of cynanchum otophyllum aglycone and application of cynanchum otophyllum aglycone in preparing medicines or healthy products, the medicines or the healthy products are used for tested persons to treat and/or prevent diseases or symptoms related to sleeping dysfunctions, insomnias and short sleeping time or calm and/or hypnotize or generate the effect of reducing spontaneous activities or central inhibitions. The invention also relates to a cynanchum otophyllum extractive. In the invention, the cynanchum otophyllum extractive and the cynanchum otophyllum aglycone both have calming and hypnotizing pharmacological activities, andcan be both used for preventing or treating the diseases related to calming and hypnotizing, and especially for preventing and treating the sleep dysfunction diseases caused by various factors.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of cyanoside (glycoside) element of plant Cynanchum otopyllum Schneid and the extract containing cynanchum otophyllum Schneid as sedative and hypnotic drugs, especially as a prophylaxis Or the use of medicines for the treatment of diseases related to sleep disorders. Background technique [0002] Cynanchum otopyllum Schneid is a plant of Asclepladaceae. There are about 180 genera and 2,200 species of Romoaceae, which are distributed in tropical, subtropical, and temperate regions of the world. There are 44 genera, 245 species and 33 varieties in China, which are distributed all over the country, but Southwest and South China are mostly distributed areas. [0003] The Kunming Institute of Botany, Chinese Academy of Sciences and other research units have conducted in-depth research on Cynanchum otophyllum Schneid. Qingyangshenside A and B (qingyangshenglv-cmideA, B), gaudatinin, qi...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61P25/20
Inventor 杨明李云峰王鲁明袁莉崔承彬董华进黄世杰闫根稳
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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