Medicament for treating idiopathic pulmonary fibrosis and preparation method thereof

A pulmonary fibrosis and idiopathic technology is applied to a drug for the treatment of idiopathic pulmonary fibrosis. In the field of preparation of the drug, it can solve problems such as the transmission of evil qi and the like.

Inactive Publication Date: 2011-03-30
支开叶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In modern society, most people use intravenous infusion of drugs or use unsuitable OTC drugs for the treatment of evil spirits. The swe

Method used

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  • Medicament for treating idiopathic pulmonary fibrosis and preparation method thereof
  • Medicament for treating idiopathic pulmonary fibrosis and preparation method thereof
  • Medicament for treating idiopathic pulmonary fibrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] a) Take 2Kg pinellia and crush it into fine powder for later use;

[0075] b) Take 3Kg of Schisandra, add 30L of 80% ethanol solution, heat and extract for 1.5h, filter, collect the filtrate, add 25L of 80% ethanol solution to the medicine residue, heat for 1h, filter, collect the filtrate, add 80% to the medicine residue % Ethanol solution 25L, heating and extracting for 1h, filtering, leaving the medicine residue for later use, combining the three ethanol extracts, recovering the ethanol and concentrating to no alcohol taste, to obtain dry extract 1;

[0076] c) Take 6.5Kg of Bupleurum and 2.5Kg of dried ginger, crush it through 24-35 mesh sieve, add 75L of water, soak for 1h, then extract 8h by steam extraction method, collect volatile oil, save water extract for later use; Dextrin: volatile oil = 8:1, β-cyclodextrin: water = 1:6 weight ratio, add volatile oil and β-cyclodextrin to water at 35°C, continue to stir for 1 hour, stand still for layering, and separate the wate...

Embodiment 2

[0081] a) Take 2.5Kg pinellia and crush it into fine powder for later use;

[0082] b) Take 4Kg schisandra and 3Kg platycodon, add 60L of 80% ethanol solution to heat extraction for 1.5h, filter, collect the filtrate, add 50L of 80% ethanol solution to the medicine residue, heat extraction for 1h, filter, collect the filtrate, and then Add 50L of 80% ethanol solution, heat and extract for 1 hour, filter, leave the medicine residue for later use, combine the three ethanol extracts, recover the ethanol and concentrate until there is no alcohol taste, to obtain dry extract 1;

[0083] c) Take 6Kg of Bupleurum and 1.5Kg of dried ginger, crush it through a 24-35 mesh sieve, add 60L of water, soak for 1h, then extract 8h by steam extraction method, collect the volatile oil, save the water extract for later use; press β cyclopaste The weight ratio of essence: volatile oil=8:1, β-cyclodextrin: water=1:6, add volatile oil and β-cyclodextrin into water at 35°C, continue to stir for 1 hour, s...

Embodiment 3

[0088] Take 3Kg of pinellia and crush into fine powder; take 4.5Kg of schisandra and 3.5Kg of platycodon, obtain dry extract 1 and medicinal residue according to step b) of Example 1; take 6.5Kg of Bupleurum and 1.5Kg of dried ginger, according to Example 2. Step c) method to obtain water extract and volatile oil β cyclodextrin inclusion compound; take 5Kg of Trichosanthis, 2.5Kg of Cassia twig, 3Kg of Scutellaria, 3Kg of Codonopsis, 2Kg of licorice, 3.5Kg of Trichosanthes, 3Kg of Cyperus rotundus, 1.5Kg of ginger Mix with 5Kg of jujube, add the above-mentioned medicinal residue and water extract, and obtain dry extract 2 according to the method in step d) of Example 2; combine dry extract 1 and dry extract 2, then add the above-mentioned pinellia powder and volatile oil The β-cyclodextrin inclusion compound is mixed evenly to obtain the active ingredient of the medicine.

[0089] Crush the active ingredients of the drug, add 5% microcrystalline cellulose, mix well, use 70% ethan...

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Abstract

The invention relates to a medicament for treating idiopathic pulmonary fibrosis. Dried ginger, schisandra, seed of snakegourd, cassia twig, bupleurum, pinellia, codonopsis pilosula, radix glycyrrhizae preparata, ginger and jujube are used as raw material medicaments and can be prepared into any common oral preparation. The medicament of the invention has the efficacy of removing evil diseases, conditioning cold and heat, relating lung qi and relieving cough and asthma, and can be used for treating the idiopathic pulmonary fibrosis. Animal test results show that the medicament of the invention can relieve abnormal change of PF I rat lung tissue, regulate free radical metabolism in a model body of rat pulmonary fibrosis, enhance the activity of GSH-Px and S0D, reduce the content of MDA and NO and effectively reduce PDGF, TGF-beta 1 and TNF-a levels in blood serum, and has the functions of preventing and treating pulmonary damage and fibrosis caused by bleomycin. Clinical tests prove that the total effective rate of the medicament for treating the idiopathic pulmonary fibrosis is up to 88.5%.

Description

Technical field [0001] The invention relates to a medicine for treating interstitial lung diseases, in particular to a medicine for treating idiopathic pulmonary fibrosis prepared by using traditional Chinese medicine as a raw material medicine. The invention also relates to a preparation method of the medicine. Background technique [0002] Interstitial lung disease (ILD) is also called diffuse interstitial lung disease (diffuse parenchymal lung disease, DPLD), which refers to a large group of lung diseases of different nature. Its histological characteristics are that the lesions are diffusely distributed in both lungs, mainly invading the surrounding lung tissues, such as alveoli, alveolar septa, small airways and small blood vessels, and lung interstitial structures. The acute phase is dominated by the infiltration of multiple cells in the alveolar wall and the exudation of alveolar cavity protein. In the subacute phase, it is dominated by granuloma. In the chronic phase, di...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P11/00
Inventor 支开叶
Owner 支开叶
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