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Medicinal application and preparation method of shorthorned epimedium P.E

A technology of epimedium extract and icariin, which is applied in the field of pharmaceutical use of epimedium extract, can solve the problem of unspecified species, great difference in quality of epimedium, different medicinal effect material basis, etc. problem, to achieve the effect of good treatment effect, quality uniformity and exact curative effect

Active Publication Date: 2011-04-13
XIUZHENG PHARMA GROUP HOIDING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The Epimedium involved in the above report did not indicate the specific species, Epimedium is the Berberidaceae Epimedium brevicornum Maxim., Epimedium sagiyyatum (Sieb. et Zucc.) Maxim. , the dry aerial part of Epimedium pubescens Maxim., Epimedium wushanense T.S.Ying or Epimedium koreanum Nakai, the quality of Epimedium varies greatly between different species, and the basis of medicinal substances not the same

Method used

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  • Medicinal application and preparation method of shorthorned epimedium P.E
  • Medicinal application and preparation method of shorthorned epimedium P.E
  • Medicinal application and preparation method of shorthorned epimedium P.E

Examples

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Embodiment 1

[0073] Example 1 Epimedium extract extraction preparation process 1

[0074] Take Epimedium medicinal material and add 70% ethanol to reflux extract twice, add 15 times of ethanol each time, each time is 1.5h, combine the extracts, concentrate until the relative density is 1.02 at 70°C, and use the polyamide adsorption method for the filtrate Refined, the sample volume is Epimedium medicinal material: polyamide = 2:1, first eluted with 1 times column volume of water, discarded the water eluate, then eluted with 5 times column volume 50% ethanol solution, collected and washed Deliquoring, recovering ethanol to obtain Epimedium extract. Wherein the total flavonoid content is 57.6%, and the icariin content is 10.2%.

Embodiment 2

[0075] Example 2 Epimedium extract extraction preparation process 2

[0076] Take Epimedium medicinal material and add water to decoct 3 times, add 20 times of water each time, each time is 1h, combine the extracts, concentrate to a relative density of 1.05 at 70°C, add ethanol to make the alcohol content 70%, static Leave it for 24 hours, take the supernatant to recover ethanol until there is no alcohol smell, add water to the liquid: medicinal material ratio 2:1, let it stand for 48 hours, filter, and the filtrate is refined by polyamide adsorption method, and the sample amount is Epimedium medicinal material: polyamide = 2:1, first eluted with 1 column volume of water, discarded the water eluate, then eluted with 3 column volumes of 70% ethanol solution, collected the eluate, recovered ethanol to obtain Epimedium extract. Wherein the total flavonoid content is 66.7%, and the icariin content is 11.4%.

Embodiment 3

[0077] Example 3 Epimedium extract extraction preparation process 3

[0078] Take Epimedium medicinal material and add 70% ethanol to reflux extract twice, add 15 times of ethanol each time, each time is 1.5h, combine the extracts, concentrate until the relative density is 1.02 at 70°C, and the filtrate is adsorbed by macroporous resin Refined by the method, the loading amount is Epimedium medicinal material: macroporous resin = 2:1, first eluted with 1 times column volume of water, discarded the eluent, then eluted with 2 times column volume of 20% ethanol, discarded Remove the eluate, and finally elute with 10 column volumes of 80% ethanol solution, collect the eluate, recover ethanol to obtain Epimedium extract. Wherein the total flavonoid content is 68.4%, and the icariin content is 9.7%.

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Abstract

The invention discloses medicinal application and an extracting method of shorthorned epimedium P.E, belonging to the field of medicines. The shorthorned epimedium P.E containing icariin, icariin A, icarisid II and epimedin B is applied to preparing medicines for treating chronic bacterial prostatitis, chronic nonbacterial prostatitis and hyperplasia of the prostate. The preparation method comprises the following steps: adding water or ethanol to epimedium for extraction; concentrating the extracting solution until the relative density is 1.01-1.10 at the temperature of 70 DEG C; and refining the filter liquor by a polyamide adsorption method, thus obtaining the shorthorned epimedium P.E. The invention has the following beneficial effects: by comparing data obtained in pharmacological tests with the data in related documents and patents, the medicines for treating chronic prostatitis and chronic hyperplasia of the prostate, which are prepared from the ehorthorned epimedium P.E, have definite curative effect, have no side effects and also have treatment effect superior to that of the prior art.

Description

technical field [0001] The present invention belongs to medical reasons, and in particular relates to the pharmaceutical use of Epimedium extract. Background technique [0002] Epimedium is the plants of Berberidaceae Epimedium brevicornum Maxim., Epimedium sagiyyatum (Sieb.et Zucc.) Maxim., Epimedium pubescens Maxim., Epimedium wushanense T.S. Ying or the dry aerial part of Epimedium koreanum Nakai. Harvest in summer and autumn when the stems and leaves are luxuriant, remove thick stems and impurities, and dry in the sun or in the shade. Epimedium is a traditional kidney-tonifying traditional Chinese medicine in my country. It is recorded in "Compendium of Materia Medica" that it "benefits essence and energy, strengthens bones and muscles, strengthens waist and knees, and strengthens heart". , expelling rheumatism" and other effects. Epimedium mainly contains flavonoids, polysaccharides, lignans, alkaloids and other chemical components. Modern pharmacological experimenta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61P13/08A61P31/04
Inventor 高陆杨星钢
Owner XIUZHENG PHARMA GROUP HOIDING
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