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Nasosinusitis soft capsule pharmaceutical preparation and preparation method thereof

A soft capsule and biyuan technology, applied in the field of traditional Chinese medicine, can solve the problems of difficult disintegration and many missed pills, and achieve the effects of preserving active ingredients, fast extraction and high efficiency.

Active Publication Date: 2011-05-11
杭州海王生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to optimize the raw material extraction process of Biyuan Soft Capsules, and to improve the problems of many missing pills and difficult disintegration of the existing product pressed pills.

Method used

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  • Nasosinusitis soft capsule pharmaceutical preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Extract volatile oil

[0040] The parameters of supercritical carbon dioxide extraction of volatile oil are as follows: crush 93.75 kg of dried magnolia, 31.25 kg of honeysuckle, and 31.25 kg of wild chrysanthemum into 40 meshes, mix them and put them into a supercritical carbon dioxide extraction kettle in batches, adjust the temperature of the extraction kettle to 50°C, and the pressure 25MPa; the temperature of the separation tank is 15°C, and the pressure is 8MPa; the flow rate of carbon dioxide gas in the pipeline is adjusted to 20±5Kg / h for volatile oil extraction. The extraction time is 2.5 hours. Under this condition, the volatile oil is about 480g, and the yield is 3.1%, which is higher than the general steam distillation and hot water reflux method.

[0041] 2) Preparation of Biyuan Soft Capsules

[0042] The method for preparing Biyuan soft capsule according to claim 1, may further comprise the steps:

[0043] (1) Preparation of contents

[0044] 1. The...

Embodiment 2

[0059] 1) Extract volatile oil

[0060] The parameters of supercritical carbon dioxide extraction of volatile oil are as follows: crush 75kg of dried magnolia, 25kg of honeysuckle, and 25kg of wild chrysanthemum to 20 meshes, mix them and put them into a supercritical carbon dioxide extraction kettle in batches, adjust the temperature of the extraction kettle to 35°C, and the pressure to 30MPa; The temperature of the kettle is 20°C, and the pressure is 6MPa; the flow rate of carbon dioxide gas in the pipeline is adjusted to 25±5Kg / h, and the volatile oil is extracted. The extraction time was 2 hours. Under this condition, the volatile oil was about 377g, and the yield was 3.0%.

[0061] 2) Preparation of Biyuan Soft Capsules

[0062] (1) Preparation of content

[0063] ① Mix about 377g of the volatile oil extracted from magnolia, honeysuckle, and wild chrysanthemum with 2kg of safflower seed oil, and mix well;

[0064] ② Add 1 kg of beeswax to 8 kg of safflower oil, heat to...

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Abstract

The invention relates to a nasosinusitis soft capsule pharmaceutical preparation for treating rhinosinusitis and a preparation method thereof. The preparation method comprises the following steps: taking Chinese traditional medicine fructus xanthil, magnolia flower, madder, wild chrysanthemum flower and honeysuckle as raw materials; extracting the raw materials; then adding a certain ratio of vegetable oil, soya bean lecithin and bee wax; and pressing to obtain the soft capsule preparation. In the invention, a supercritical carbon dioxide method is used for extracting volatile oil, thus compared with the existing vapor distillation and hot water reflux methods, the extraction yield is increased by 1-3%; the soya bean lecithin is added into the content, thus improving the liquidity of the content, and lowering the pill leaking rate of the product (less than 0.1per mill); and by adjusting the ratio of capsule shell components, the problems that a capsule shell is hardened and tendered and can not be easily disintegrated after being placed for a long time are solved, and the appearance of the capsule shell is elegant.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a soft capsule pharmaceutical preparation for treating rhinitis and sinusitis and a preparation method thereof. technical background [0002] Chronic rhinitis and sinusitis are one of the common and frequently-occurring diseases in otolaryngology. In traditional Chinese medicine, they belong to the categories of "nasal obstruction", "congested nose" and "nasal sinusitis". Biyuan refers to a rhinopathy characterized by a runny nose, which oozes down like a spring, and is often accompanied by headache, nasal congestion, hyposmia, pain in the sinus area, and long-term dizziness. The main treatment principles of Biyuan in contemporary Chinese medicine are "dispelling wind, clearing heat, and promoting dampness". The main drugs used are: cocklebur, magnolia, honeysuckle, wild chrysanthemum and so on. [0003] Currently, there are Biyuan Tablets, Biy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/48A61K47/44A61P11/02
Inventor 李文霞刘勇赵耘柏金霞朱妙飞戴晶晶上官海燕郭靖
Owner 杭州海王生物工程有限公司
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