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Traditional Chinese medicinal composition and preparation method and application thereof

A technology of composition and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine composition, can solve the problems of complex varieties, high prices, and unclear active ingredients

Active Publication Date: 2011-05-18
隋殿军 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many types of drugs for the treatment of ischemic cerebrovascular diseases, the drug prescriptions are broad, the active ingredients are not clear, and the price is high

Method used

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  • Traditional Chinese medicinal composition and preparation method and application thereof
  • Traditional Chinese medicinal composition and preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0018] A preparation method of a Chinese medicine composition, comprising the following steps:

[0019] a, take Chuanxiong powder, through supercritical CO 2 Fluid extraction treatment, the extracted volatile oil is made into clathrate with 4 to 10 times the amount of β-cyclodextrin; the dregs are decocted with 4 to 10 times the amount of water, the decoction is filtered, the filtrate is centrifuged, and the supernatant Pass through a filter membrane with a molecular cut-off of 3000-20000, concentrate the filtrate, spray dry it, mix it with the clathrate, and set aside;

[0020] b. Take pueraria root powder, extract with 4-10 times the amount of 30%-80% ethanol under reflux, filter the extract, recover ethanol from the filtrate, add water to stand, filter, and concentrate the filtrate to 0.3-1.0g / ml; Resin purification, eluting with ethanol, collecting the eluate, recovering ethanol, spray drying, and set aside;

[0021] c. Mix the standbys obtained in step a and step b even...

example 1

[0029] The preparation of example 1 capsule

[0030] Chuanxiong 500g, CO 2 Supercritical fluid extraction for 1.5 hours, extraction temperature 45°C, extraction pressure 30MPa, volatile oil with 6 times the amount of β-cyclodextrin using grinding method to make clathrate; medicinal dregs plus 5 times the amount of water decoction 3 times, 1.5 hours each time , combined the decoction and the distilled aqueous solution, filtered, high-speed centrifugation (3000rpm / min), the supernatant passed through a filter membrane with a molecular cut-off of 5000, the filtrate was concentrated, spray-dried, and the extract was obtained for use.

[0031] Pueraria 500g, add 6 times the amount of 40% ethanol to reflux and extract 3 times, 2 hours each time, combine the extracts, filter, recover ethanol from the filtrate, add water to 180ml, stand still for 24 hours, filter, and concentrate the filtrate to 0.8g medicinal materials / ml , purified by using 1 / 2.5 medicinal material amount AB-8 type...

example 2

[0033] The preparation of example 2 tablet

[0034] Chuanxiong 500g, CO 2 Supercritical fluid extraction for 2 hours, extraction temperature 50°C, extraction pressure 40MPa, volatile oil with 7 times the amount of β-cyclodextrin using grinding method to make clathrate; dregs plus 5 times the amount of water decoction 3 times, 2.5 hours each time , combined the decoction and the distilled aqueous solution, filtered, high-speed centrifugation (4000rpm / min), the supernatant passed through a filter membrane with a molecular cut-off of 8000, the filtrate was concentrated, spray-dried, and the extract was obtained for use.

[0035] Pueraria 500g, add 8 times the amount of 60% ethanol to reflux and extract 3 times, 1.5 hours each time, combine the extracts, filter, recover ethanol from the filtrate, add water to 180ml, stand still for 24 hours, filter, and concentrate the filtrate to 0.5g medicinal materials / ml , purified by D101 type resin (dry weight) with 1 / 3.3 amount of medicina...

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Abstract

The invention relates to a method for preparing a traditional Chinese medicinal composition, which comprises the following steps of: a, extracting szechuan lovage rhizome powder by using supercritical CO2 fluid, and preparing an inclusion compound from the extracted volatile oil by using beta-cyclodextrin in an amount which is 4 to 10 times volume of the volatile oil; and decocting medicine dregsby adding water in an amount which is 4 to 10 times weight of the medicine dregs, filtering the decoction, centrifuging the filtrate, making the supernatant pass through a filter membrane with the molecular intercepting quantity of 3,000 to 20,000, concentrating the filtrate, performing spray drying, and uniformly mixing with the inclusion compound for later use; b, performing reflux extraction on puerariae root powder by using 30 to 80 percent ethanol in an amount which is 4 to 10 times weight of the puerariae root powder, filtering the filtrate, recovering the ethanol from the filtrate, adding water, standing, filtering, and concentrating the filtrate to achieve the concentration of 0.3 to 1.0 g / ml; and purifying through a macroporous resin, eluting by using the ethanol, collecting the eluent, recovering the ethanol, and performing spray drying for later use; and c, uniformly mixing the standby products obtained in the steps a and b according to a weight ratio of (1-10):(1-10). The traditional Chinese medicinal composition consisting of the szechuan lovage rhizome and the puerariae root is prepared by the method, has the effects of promoting blood circulation and removing blood stasis and dredging meridians and relieving pain, and is used for treating cerebral ischemia and cerebrovascular diseases.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, a preparation method and application of the traditional Chinese medicine composition. Background technique [0002] Ischemic cerebrovascular disease refers to a series of diseases caused by transient ischemic attack, cerebral thrombosis or cerebral embolism. The main cause is brain injury caused by insufficient blood supply to the brain, and headache, dizziness, orofacial numbness , metamorphopsia, etc. are the main clinical manifestations. The onset of ischemic cerebrovascular disease is closely related to cerebral arteriosclerosis, diabetes, and coronary heart disease. It is a common disease in middle-aged and elderly people. Its clinical manifestation is very similar to TCM syndrome of blood stasis blocking collaterals. [0003] At present, China is a country with a high incidence of ischemic cerebrovascular di...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P9/10
Inventor 隋殿军邱智东陈雪松
Owner 隋殿军
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