Compound preparation for promoting neuromuscular regeneration and preparation method thereof

A compound preparation, neuromuscular technology, applied in the direction of neuromuscular system diseases, muscular system diseases, medical preparations containing active ingredients, etc., can solve problems such as no breakthrough clinical progress, and achieve synaptic reconstruction and promote synapse reconstruction. Rapid growth and regeneration effect

Inactive Publication Date: 2011-06-15
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As early as the 1950s, foreign scholars discovered Nerve Growth Factor (NGF), and successive studies reported that NGF family (NGF, BDNF, NT-3, NT-4, NT-5, etc.) and non-NGF family (CNTF , IGF, GDNF, SDNF, etc.) a variety of different ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh the Chinese herbal medicine Codonopsis: Radix Astragali: Salvia Miltiorrhiza: Rehmannia: Angelica: Safflower 10:10:10:10:5:2, and weigh the Chinese herbal medicine Codonopsis: Astragalus: Salvia: Rehmannia: Angelica : safflower is 10:10:10:10:5:2, except for safflower, take the rest of the medicinal materials, wash them, dry them in a ventilated place, cut them into small pieces of 1-2cm, and use 4-10 times the amount of water Soak for 12 hours, decoct for 2 hours × 2 times, filter the water extract and let it stand for 12 hours, filter it again, heat and concentrate to the required volume to obtain the Chinese medicine intermediate (water extract extract), after drying, crush it into super The fine powder is 10~15μm; the fine powder is mixed evenly, and the excipients or auxiliary ingredients are added and mixed to make a compound preparation.

[0040] The compound preparation can be made into electuary, powder, granule, pill or capsule.

Embodiment 2

[0042] Weigh the Chinese herbal medicine Codonopsis: Radix Astragali: Salvia Miltiorrhiza: Rehmannia: Angelica: Safflower 10:10:10:10:5:2, and weigh the Chinese herbal medicine Codonopsis: Astragalus: Salvia: Rehmannia: Angelica : The ratio of safflower is 10:10:10:10:5:2. Except for safflower, take the rest of the medicinal materials, wash them, dry them in a ventilated place, cut them into small pieces of 1-2 cm, soak them in 8 times the amount of water for 12 hours Heat and reflux extraction 3 times, each reflux extraction time is 1 hour, the water extract is filtered and left to stand for 12 hours, then filtered once, heated and concentrated to the required volume to obtain a Chinese medicine intermediate (water extraction extract), after drying, air flow Pulverization method Pulverize into superfine powder 10~15μm; mix the fine powder evenly, add excipients or auxiliary ingredients, mix well, and make compound preparation.

[0043] The compound preparation can be made int...

Embodiment 3

[0044] Example 3 Effect experiment on rat sciatic nerve regeneration

[0045] Animals: 90 SPF grade Sprague-Dawley male rats, weighing 180g-200g (purchased from the Experimental Animal Department of Fudan University).

[0046] The rats were randomly divided into 3 groups, A, B, and C, with 30 rats in each group. Group A is the injury control group; Group B is the preparation group of the present invention; Group C is the ginkgo ketone ester group. Each group was further divided into 5 subgroups according to different time points (1, 2, 4, 6, 8w) after sciatic nerve injury, with 6 rats in each subgroup.

[0047] Equipment and medicines:

[0048] Desktop operating microscope and 10x and 16x eyepieces (SXP-1B, Shanghai Medical Optical Instrument Factory), microsurgical instruments and 11-0, 12-0 medical non-invasive suture needles and threads (Ningbo Chenghe Microscopic Instrument Factory), 3-0 mousse surgical suture (Johnson & Johnson), muscle tension transducer (SMU-PC biolo...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicaments and relates to a compound preparation for promoting neuromuscular regeneration and a preparation method thereof. The compound preparation is prepared from raw material medicaments, such as codonopsis pilosula, astragalus, root of red-rooted salvia and the like, and medicinally acceptable auxiliary materials or auxiliary ingredients according to a specific weight ratio by a water extraction method. The result of a pharmacological test shows that the compound preparation can increase GAP-43 expression in early damaged nerve, can be competitively combined to a G protein reaction site, can promote quick growth of axon and can contribute to reconstruction of synapse. The result of an animal test shows that the compound preparation promotes metabolism of an organism, increases blood supply of a damaged part, eliminates degenerated myelin sheath, promotes fission and proliferation of Schwann cells and has obvious effect of accelerating regeneration of peripheral nerves after the peripheral nerves are damaged. The compound preparation can be further prepared into a medicament clinically used for promoting neuromuscular regeneration so as to bring benefit to more patients suffered from nerve injury.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound preparation of traditional Chinese medicines, in particular to a compound preparation containing Codonopsis pilosula and other traditional Chinese medicines for promoting neuromuscular regeneration and a preparation method thereof. Background technique [0002] Trauma is one of the three major causes of death since the 20th century. In developed countries, trauma is also the first cause of death and disability among young and middle-aged adults, which brings extreme pain to patients and huge economic losses to society. With the development of modern medicine, especially the development of microsurgery after the 1960s, the survival rate after trauma has been greatly improved, and many patients have seen hope. However, among the rescued patients, there are still many injured. Can not return to the original job, because the recovery of neuromuscular function aft...

Claims

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Application Information

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IPC IPC(8): A61P21/00A61K36/804
Inventor 顾玉东方有生陈德松
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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