Slow-soluble external contraceptive membrane

A contraceptive membrane and slow-dissolving technology, which is applied in the direction of diseases, organic active ingredients, and medical preparations of non-effective ingredients, etc., can solve problems that affect the use of nonoxynol ether membranes, low contraceptive efficiency, and affect contraceptive effects. Achieve the effects of increasing anti-allergic effect, improving contraceptive effect, and good water retention performance

Inactive Publication Date: 2011-06-22
石家庄经济技术开发区利生技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After decades of clinical use, it has been found that its contraceptive efficiency is lower than other contraceptive methods, and it also has the disadvantage of being inconvenient to use, that is, it takes 5-10 minutes to have sexual intercourse after being inserted into the vagina. Well, it will also affect the contraceptive effect
Another disadvantage is the presence of local irritatio

Method used

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  • Slow-soluble external contraceptive membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Accurately measure nonoxynol-90.06g, 0.3g of hydroxypropylmethylcellulose, 0.2g of polyacrylic acid resin, 1g of polyethylene glycol, 0.5g of super sodium starch glycolate, and 2g of propylene glycol. First, hydroxypropyl methylcellulose is prepared into an aqueous solution, and polyacrylic acid resin is prepared into an alcohol solution with ethanol, and the above solution is added to nonoxynol-9, super sodium carboxymethyl starch, polyethylene glycol and propylene glycol mixture respectively, Mix thoroughly and evenly, inject into mold and / or spread on flat plate, take out and / or cut into various shapes after film formation, pack, each tablet contains about 50mg of nonoxynol ether. .

Embodiment 2

[0039] Example 2: Accurately measure 0.12g of nonoxynol-9, 0.5g of hydroxypropylmethylcellulose, 0.3g of polyacrylic acid resin latex, 2g of polyethylene glycol, 0.7g of super sodium starch glycolate, glycerin Alcohol 2g. First prepare hydroxypropyl methylcellulose into an aqueous solution, dilute the polyacrylic acid resin latex with water to a suitable concentration, and add nonoxynol-9, super sodium carboxymethyl starch, polyethylene glycol and glycerin to the above solution respectively In the alcohol mixture, mix well, pour into the mold and / or spread on the plate, take out and / or cut into various shapes after film formation, pack, each piece contains about 100mg of nonoxynol ether.

[0040] Other embodiment each component and consumption thereof are different from embodiment 1, 2 and see the table below: unit: gram

[0041]

[0042] According to needs, the present invention can also be made into ointment, suppository, gel and other dosage forms by adjusting the conte...

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PUM

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Abstract

The invention discloses a slow-soluble external contraceptive membrane. The contraceptive membrane is prepared from the raw materials such as 0.05 to 1.5 parts of nonoxinol-9, 0.3 to 2 parts of super carboxymethyl starch sodium, 0.3 to 3 parts of hydroxypropyl methyl cellulose, 0.1 to 0.3 part of polyacrylic resin film agent, 1 to 3 parts of polyethylene glycol, 2 to 10 parts of lubricating agent and the like. The contraceptive membrane prepared by using the material composition has slow solubility and high medicament dissolution, and has effects of absorbing seminal fluid and killing sperms. After the contraceptive membrane prepared from the materials is put into the vagina, sexual intercourse can be performed immediately, and waiting is not needed. The stiff and smooth membrane shape is kept for 3 hours when the contraceptive membrane is not contacted with the seminal fluid, and sperm killing medicaments are slowly released, so that loss of the sperm killing medicaments in short time can be avoided; and the release of the sperm killing medicaments is accelerated when the contraceptive membrane is contacted with the seminal fluid, and the performance ensures high efficiency of the sperm killing medicaments and can improve the contraceptive effect. The membrane material has good compatibility with vaginal mucosa, has irritability resistance, flexibility and comfort, and can eliminate the stimulation effect of the nonoxinol-9 on the skin mucosa.

Description

technical field [0001] The invention relates to a contraceptive film material composition, in particular to a slow-dissolving external contraceptive film. Background technique [0002] The nonoxynol film currently used in the market is a dry paper-like film that melts within 3 minutes when it meets water. In the process of pushing it into the vagina with your fingers, the film can absorb vaginal secretions and stick to your fingers, making the medicine Concentration decreased. After decades of clinical use, it has been found that its contraceptive efficiency is lower than other contraceptive methods, and it also has the disadvantage of being inconvenient to use, that is, it takes 5-10 minutes to have sexual intercourse after being inserted into the vagina. Well, it will also affect the contraceptive effect. Another disadvantage is the presence of local irritation. After use, most people will experience adverse reactions such as local burning sensation, increased secretions...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/085A61K47/38A61P15/18
Inventor 李荣秀胡殿珍范国荣赵凯军牛慧蒙周艳川
Owner 石家庄经济技术开发区利生技术开发有限公司
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