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Pharmaceutical composition comprising cycloartenyl ferulate

A technology of pineapple enol ferulate and a composition, applied in the field of medicine, can solve the problems of low solubility, inability to solve the problems of pineapple enol ferulate being insoluble in water and the like

Active Publication Date: 2011-07-20
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the research on the pure product of cycloartenol ferulate, the applicant found that its solubility in water is lower than that of oryzanol raw material, only about 1 / 3 of the solubility of oryzanol. The traditional technology used to solve the solubilization of oryzanol None of the schemes can solve the insoluble problem of cycloartenyl ferulic acid ester

Method used

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  • Pharmaceutical composition comprising cycloartenyl ferulate
  • Pharmaceutical composition comprising cycloartenyl ferulate
  • Pharmaceutical composition comprising cycloartenyl ferulate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 40g of s6 and heat it to a molten state at 60°C, then add 8g of cycloxylene alcohol ferulate to it, mix and stir for 15min, add the resulting molten liquid to 5L of water for injection and stir evenly until it is completely dissolved. The pharmaceutical composition of the invention has a concentration of 1.6 mg / ml.

[0029] The resulting solution was completely clear at room temperature for 24 hours.

Embodiment 2

[0031] Take 100g of s20 and heat it to a molten state at 60°C, then add 10g of cycloxylene alcohol ferulate to it, mix and stir for 30min, add the resulting molten liquid to 5L of water for injection and stir evenly until it is completely dissolved. The pharmaceutical composition of the invention has a concentration of 2 mg / ml.

[0032] The resulting solution was completely clear at room temperature for 24 hours.

Embodiment 3

[0034] Take 200g of s40 and heat it to a molten state at 70°C, then add 5g of cycloxylene alcohol ferulic acid ester to it, mix and stir for 40min, add the resulting molten liquid to 4L of water for injection and stir evenly until it is completely dissolved. The pharmaceutical composition of the invention has a concentration of 1.25 mg / ml.

[0035] The resulting solution was completely clear at room temperature for 24 hours.

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Abstract

The invention discloses a pharmaceutical composition comprising cycloartenyl ferulate, which solves the problem that cycloartenyl ferulate is insoluble in water. The pharmaceutical composition disclosed by the invention comprises cycloartenyl ferulate and polyoxyl[40]stearate. A stable and water-soluble oryzanol pharmaceutical composition solution is obtained by adding cycloartenyl ferulate into molten polyoxyl[40]stearate. Further, the invention discloses a preparation method of the pharmaceutical composition solution and applications of the preparation.

Description

Technical field [0001] The invention discloses a pharmaceutical composition of cycloxylene alcohol ferulate, which comprises cycloxylene alcohol ferulate and polyoxyl stearate, and belongs to the field of medicine. Background technique [0002] Oryzanol is a natural mixture composed of ferulic acid esters with cylindropine alcohols as the main body and ferulic acid esters of sterols. The main two components are cylindropineol ferulate and 24-ylidene acid. Methylcyclopineapple alcohol ferulate, the content of both in the unpurified oryzanol is about 70%, and it is the main active ingredient in oryzanol. Long-term studies have found that oryzanol has a variety of pharmacological activities, such as lowering blood lipids, reducing cholesterol absorption, preventing lipid oxidation, preventing cardiovascular diseases, alleviating various physical disorders and autonomic nervous disorders after women enter menopause, and improving diencephalon function Imbalance. [0003] In the exist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K47/32A61K47/24A61K47/10A61K47/16A61P3/06A61P9/00A61P15/12A61P25/00
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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