Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of pharmaceutical compositions for treating and preventing cardiovascular and cerebrovascular diseases, and pharmaceutical compositions for relaxing cardiovascular and cerebrovascular smooth muscles

Active Publication Date: 2011-07-20
北京富丽华德生物医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But do not see so far, pomegranate juice or the report that the pharmaceutical composition containing pomegranate juice relaxes vascular smooth muscle, the applicant has found a kind of traditional Chinese medicine composition containing pomegranate juice etc. that provides the effect of relaxing vascular smooth muscle

Method used

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  • Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases
  • Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases
  • Pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental Example 1 The relaxing effect of the pharmaceutical composition of the present invention on the aortic vessels of mice

[0038] The mice were 100 male Kunming mice over 3 weeks old, purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences. Use granular formulations to feed mice, 2 times a day, 2 mg samples each time, 20 mice fed the pharmaceutical composition were tested on 20, 40, 60, 80, and 100 days, and 20 mice were used as a blank control . The result is figure 1 Shown. The relaxation rate is determined by rapidly removing the thoracic aorta after killing the mouse, peeling off the surface fat and part of the connective tissue, cutting into a 4mm aortic vascular ring, and placing the sample in 10ml Krebs solution (Krebs The liquid contains parts by weight of NaCl 119.0, KCl 4.7, and CaCl 2 2.5, KH 2 PO 4 1.2, MgSO 4 1.2, NaHCO 3 25.0 and glucose 10.0 and water 1000). During the experiment, the pH was stabilized at 7....

experiment example 2

[0039] Experimental Example 2 The effect of the pharmaceutical composition of the present invention on the cardiovascular system of white rabbits.

[0040] Methods: Japanese big-eared white rabbits (purchased from Xi'an Di Lepu Biological Resources Development Co., Ltd., specification 2010-003, were divided into sample group and control group. The sample group was given a liquid dosage form and intravenously administered 12 mg / kg sample. From the rabbit Take blood from the middle ear artery to determine the plasma cGMP content and various indexes of hemorheology

[0041] Results: a. Changes in plasma cGMP content

[0042] After taking the sample at 12 mg / kg, the plasma cGMP content increased significantly, reaching a peak in 2 hours. The detection method is the same as Experimental Example 1, and the results are shown in Table 1.

[0043] b. Changes in blood viscosity

[0044] After taking the sample, the whole blood viscosity decreased significantly, and the decrease was the most sig...

Embodiment 2

[0064] Example 2 illustrates that the pharmaceutical composition of the present invention can be used to improve the content of cGMP, regulate vasodilation, reduce blood viscosity and reduce platelet aggregation, and can be used to treat or prevent vasospasm-related diseases and atherosclerosis-related diseases .

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases, containing 80 parts by weight of grenadine juice, 180 parts by weight of antioxidant and a pharmaceutically acceptable carrier, wherein the antioxidant is one or the composition of many of the raw materials or raw material extracts or raw material concentrates of rice hull,carrot, pumpkin, cinnamon, broccoli, strawberry, blueberry, raspberry, green tea, sealwort, bitter caramon, tomato, pumpkin seed, resveratrol, vitamin E, vitamin C, grape pip, Brazil nut, Brazil large cherry, barley bran, rosemary, walnut leaf, tamarindus seed coat, cabbage, spinach, garlic and the like. The pharmaceutical composition provided by the invention has certain application values in treating or preventing cardiovascular and cerebrovascular diseases, treating or preventing hypertension, treating or preventing cardiovascular smooth muscle spasm and expanding the vascular smooth muscle.

Description

Technical field [0001] The invention belongs to the field of medicines and health products, and relates to a pharmaceutical composition for treating and preventing cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition for relaxing the smooth muscle of the heart and brain vessels. Background technique [0002] Cardio-cerebral vascular smooth muscle spasm can cause a variety of diseases, such as high blood pressure, coronary artery spasm, heart disease (such as angina, myocardial infarction, etc.), cerebral vasospasm disease (insufficient blood supply to the brain, migraine), peripheral vasospasm disease (multiple Arteritis, Raynaud’s syndrome) and pulmonary hypertension. Among them, hypertension is the disease with the highest incidence of cardiovascular diseases in our country. Continued high blood pressure can cause complications such as stroke, heart disease, hemangioma, renal failure, etc., and seriously endanger the health of our people. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/23A61K36/31A61K36/42A61K36/45A61K36/48A61K36/52A61K36/53A61K36/54A61K36/73A61K36/736A61K36/81A61K36/82A61K36/87A61K36/8962A61K36/8969A61K36/899A61K36/8998A61K36/9062A61P9/10A61K31/05A61K31/355A61K31/375
Inventor 刘万涛陈振兴苏雨雷
Owner 北京富丽华德生物医药科技股份有限公司
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