Pediatric nasal medicine for treating upper respiratory tract infection and preparation method thereof

An upper respiratory tract and pediatric technology, applied in the field of pediatric nasal medicine and its preparation, can solve the problems of unsuitability for children, toxic nasal cilia, and children's medication resistance, and achieves reduction of drug loss, promotion of drug absorption, and good safety. Effect

Inactive Publication Date: 2011-08-10
葛翠萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are the following problems in nasal medication for children with upper influenza: ① unnatural surfactants and additives are often used in adult nasal drug formulations, which are potentially toxic to children; ② adult nasal drug formulations often contain vasoconstrictors, ephedrine, etc. Suitable for children; ③Due to the mechanism of nasal cilia swinging and clearing, the retention time in the nasal cavity is only 20 to 30 minutes. Therefore, in order to speed up local absorption, the current nasal administration preparations are often added with absorption enhancers, such as β-cyclodextrin, polyethylene glycol, etc. Glycol, Tween, chitosan, etc. Absorption accelerators are toxic to nasal cilia, and the damage caused by them is often irreversible, which limits the application of nasal administration in pediatrics; Penetration enhancers such as menthol and borneol are added to stimulate the nasal cavity of children, causing drug resistance in children

Method used

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  • Pediatric nasal medicine for treating upper respiratory tract infection and preparation method thereof
  • Pediatric nasal medicine for treating upper respiratory tract infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1, the weight ratio of raw materials: 14 parts of Angelica dahurica, 10 parts of bellflower, 10 parts of burdock, 10 parts of honeysuckle, 10 parts of mulberry leaves, 6 parts of almond, 14 parts of wild chrysanthemum, 14 parts of coriander, 1 part of scallion , 3 parts of peach gum.

[0038] The preparation method is as follows:

[0039] (1) Boil scallion white for 0.5 hours, filter the cooking liquid, add crushed peach gum coarse powder to the cooking liquid, heat at 80°C until the peach gum is completely melted, concentrate to a relative density of 1.20-1.25, add cold water drop by drop while heating Cool in medium, take out and dry in the shade to become rubber beads for later use;

[0040] (2) Angelica dahurica, coriander, wild chrysanthemum, almond, and burdock fruit were crushed into powder, passed through a 20-mesh sieve, mixed, and extracted with supercritical carbon dioxide circulation countercurrent for 1 hour, the extraction pressure was 5 MPa, and ...

Embodiment 2

[0043] Example 2, the weight ratio of the bulk drug is the same as in Example 1, the difference between the preparation method and Example 1 is that step 4 is: freeze-dry the raw material obtained in step 3, dry and pulverize it by pulverization, and control the particle diameter of the obtained active particles to 20 ~50um.

Embodiment 3

[0044] Example 3, the weight ratio of raw materials: 20 parts of Angelica dahurica, 16 parts of bellflower, 16 parts of burdock, 16 parts of honeysuckle, 16 parts of mulberry leaves, 10 parts of almond, 20 parts of wild chrysanthemum, 20 parts of coriander, 2 parts of scallion , 5 parts of peach gum.

[0045] The preparation method is as follows:

[0046] (1) Boil scallion white for 1 hour, filter the cooking liquid, add crushed peach gum coarse powder to the cooking liquid, heat at 100°C until the peach gum is completely melted, concentrate to a relative density of 1.25-1.3, add cold water drop by drop while heating Cool in medium, take out and dry in the shade to become rubber beads for later use;

[0047] (2) Angelica dahurica, peony coriander, wild chrysanthemum, almond, and burdock fruit were crushed into powder, passed through a 20-mesh sieve, mixed, and subjected to countercurrent extraction with supercritical carbon dioxide circulation for 6 hours at an extraction press...

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Abstract

The invention discloses a pediatric nasal medicine for treating upper respiratory tract infection and a preparation method thereof for relieving nasal symptoms of infants suffering from upper respiratory tract infection. The pediatric nasal medicine for treating upper respiratory tract infection is characterized in that the raw medical materials comprise angelica dahurica, balloon flower, burdock, honeysuckle, mulberry leaves, almond, wild chrysanthemum flower, centipeda minima, allium fistulosum and peach gum. The preparation method of the pharmaceutical composition comprises the following steps of: cooking the allium fistulosum into liquor, heating and melting the peach gum, concentrating and cooling into gel beads for later use; carrying out circular countercurrent extraction on the angelica dahurica, the peda minima, the wild chrysanthemum flower, the almond and the burdock with supercritical carbon dioxide to obtain hybrid naphtha for later use; aqueously extracting the balloon flower, the honeysuckle and the mulberry leaves, concentrating and adding the gel beads under heating and stirring to grind so as to dissolve; and cooling to 40-50 DEG C, adding under stirring, mixing uniformly, drying and crushing to obtain active grains with the diameters of 20-100 micros. Proved by experimental research, the invention has the advantages of good curative effect and higher safety.

Description

【Technical field】 [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pediatric nasal medicine for treating upper respiratory tract infection and a preparation method thereof. 【Background technique】 [0002] Upper respiratory tract infection, referred to as upper respiratory tract infection, is a common disease in childhood, and it is a general term for acute inflammation between the nasal cavity and the throat. Due to the imperfect development and physiological function of the nose in childhood, local nasopharyngeal inflammatory symptoms are more likely to occur during the upper respiratory tract, that is, catarrhal symptoms, which are manifested as nasal mucosal congestion, flushing, swelling, frequent sneezing, and subsequent Nasal discharge from one or both nostrils. Because children's nasal cavity inflammatory stimulation can easily cause acute adenoiditis in children, long-term inflammatory stimulation can lead to adenoid hype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/16A61P11/00
Inventor 葛翠萍葛玉文
Owner 葛翠萍
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