Pediatric nasal medicine for treating upper respiratory tract infection and preparation method thereof

Abstract

The invention discloses a pediatric nasal medicine for treating upper respiratory tract infection and a preparation method thereof for relieving nasal symptoms of infants suffering from upper respiratory tract infection. The pediatric nasal medicine for treating upper respiratory tract infection is characterized in that the raw medical materials comprise angelica dahurica, balloon flower, burdock, honeysuckle, mulberry leaves, almond, wild chrysanthemum flower, centipeda minima, allium fistulosum and peach gum. The preparation method of the pharmaceutical composition comprises the following steps of: cooking the allium fistulosum into liquor, heating and melting the peach gum, concentrating and cooling into gel beads for later use; carrying out circular countercurrent extraction on the angelica dahurica, the peda minima, the wild chrysanthemum flower, the almond and the burdock with supercritical carbon dioxide to obtain hybrid naphtha for later use; aqueously extracting the balloon flower, the honeysuckle and the mulberry leaves, concentrating and adding the gel beads under heating and stirring to grind so as to dissolve; and cooling to 40-50 DEG C, adding under stirring, mixing uniformly, drying and crushing to obtain active grains with the diameters of 20-100 micros. Proved by experimental research, the invention has the advantages of good curative effect and higher safety.

Description

【Technical field】 [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pediatric nasal medicine for treating upper respiratory tract infection and a preparation method thereof. 【Background technique】 [0002] Upper respiratory tract infection, referred to as upper respiratory tract infection, is a common disease in childhood, and it is a general term for acute inflammation between the nasal cavity and the throat. Due to the imperfect development and physiological function of the nose in childhood, local nasopharyngeal inflammatory symptoms are more likely to occur during the upper respiratory tract, that is, catarrhal symptoms, which are manifested as nasal mucosal congestion, flushing, swelling, frequent sneezing, and subsequent Nasal discharge from one or both nostrils. Because children's nasal cavity inflammatory stimulation can easily cause acute adenoiditis in children, long-term inflammatory stimulation can lead to adenoid hype...

AI Technical Summary

Problems solved by technology

At present, there are the following problems in nasal medication for children with upper influenza: ① unnatural surfactants and additives are often used in adult nasal drug formulations, which are potentially toxic to children; ② adult nasal drug formulations often contain vasoconstrictors, ephedrine, etc. Suitable for children; ③Due to the mechanism of nasal cilia swinging and clearing, the retention time in the nasal cavity is only 20 to 30 minutes. Therefore, in order to speed up local absorption, the current nasal administration preparations are often added with absorption enhancers, such as β-cyclodextrin, polyethylene glycol, etc. Glycol, Tween, chitosan, etc. Absorption accelerators are toxic to nasal cilia, and the damage caused by them is often irreversible, which limits the application of nasal administration in pediatrics; Penetration enhancers such as menthol and borneol are added to stimulate the nasal cavity of children, causing drug resistance in children

Images