Gingko flavanone aglycone dropping pills and preparation method thereof

Abstract

The invention discloses a gingko flavanone aglycone dropping pills and a preparation method thereof. The dropping pills are prepared from gingko flavanone aglycone, a matrix and an antioxidant, wherein the matrix is polyethylene glycol 4000 to polyethylene glycol 10000; the antioxidant is vitamin C; the mass ratio of the gingko flavanone aglycone to the matrix is 1:(10-1):80; and the antioxidant accounts for 1 to 3 percent of all the materials. The preparation method comprises the following steps of: (1) uniformly mixing the gingko flavanone aglycone and the matrix in proportion, adding the vitamin C into the mixture, uniformly mixing, stirring and heating the mixture in a heating container until the mixture is melted, and preserving the heat; (2) adjusting the dropping disc temperature of a pill dropping machine to be between 65 and 85 DEG C and the temperature gradient of condensate to be between 30 and 10 DEG C to be between 4 and -4 DEG C; (3) dropping the melted material into the condensate through a dropping head on a dropping disc; and (4) taking out concentrated and formed dropping pills from the outlet of the pill dropping machine, removing the condensate, and drying the dropping pills to obtain the gingko flavanone aglycone dropping pills. The dropping pills have quick effect and high bioavailability and medicament stability and are suitable for industrial production.

Description

technical field [0001] The present invention relates to medicinal preparations containing plants, in particular to ginkgo flavonoids, and further to ginkgo flavonoid aglycone preparations. Background technique [0002] The flavonoids in the leaves of Ginkgo biloba L. usually exist in the form of inactive glycosides, and only after being decomposed by the glucosidase of the intestinal flora, the flavonoid aglycones of Ginkgo biloba are biologically active; The glycoside ginkgo flavonoids decomposed by the flora are not easy to be absorbed, and are directly excreted from the bile into the intestinal tract. Many studies have shown that ginkgo flavonoid aglycone has a variety of biological activities. In addition to antibacterial, anti-inflammatory, anti-mutation, antihypertensive, heat-clearing and detoxifying, sedative, diuretic, etc., it also has anti-oxidation, anti-cancer, anti-cancer, and inhibition of lipase. Significant effect. At present, the preparations containing g...

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