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Compound Chinese actinidia root Chinese medicinal composition and preparation method and application thereof

The technology of compound vine pear and composition is applied in the field of compound vine pear root traditional Chinese medicine composition, which can solve the problems of high price, large toxic and side effects, easy to cause drug resistance and the like, and achieve the effect of good effect

Inactive Publication Date: 2011-10-05
ZHEJIANG SIXIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most chemotherapeutic drugs used in domestic cancer clinical treatment have the problems of poor targeting, high toxicity and side effects, and easy to cause drug resistance. A few drugs with better curative effect mainly rely on imports and are expensive, which brings heavy burden to cancer patients. burden

Method used

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  • Compound Chinese actinidia root Chinese medicinal composition and preparation method and application thereof
  • Compound Chinese actinidia root Chinese medicinal composition and preparation method and application thereof
  • Compound Chinese actinidia root Chinese medicinal composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Weigh each API according to the following weight ratio (take ten times the ratio of API as an example):

[0030] 600 parts of vine pear root,

[0031] Iwami wears 300 copies,

[0032] 300 copies of Scutellaria barbata,

[0033] Hedyotis diffusa 300 parts,

[0034] 300 parts of knotweed.

[0035] (2) Soak Tengligen, Shijianchuan, Banzhilian, Hedyotis diffusa, Polygonum cuspidatum plus 8 times the weight of medicinal materials in the above weight ratio for 0.5 hours, heat and reflux for 2 hours, filter, collect the filtrate, and filter residue Add 6 times the weight of medicinal materials in water, heat and reflux to extract for 1.5 hours, filter, collect the filtrate, combine the two filtrates, concentrate, put the liquid extract in an oven at 80°C and bake it until it is completely dry, then crush it into a fine powder (through a 80-mesh sieve) ).

[0036] (3), take 75 parts of the fine powder of medicine prepared above, add 5 parts of starch, 4 parts of 8% sta...

Embodiment 2

[0038] (1) Weigh each API according to the following weight ratio (take ten times the ratio of API as an example):

[0039] 600 parts of vine pear root,

[0040] Iwami wears 300 copies,

[0041] 300 copies of Scutellaria barbata,

[0042] Hedyotis diffusa 300 parts,

[0043] 300 parts of knotweed.

[0044](2) Soak the vine pear root, Shi Jianchuan, Scutellaria barbata, Hedyotis diffusa, Polygonum cuspidatum plus 8 times the weight of medicinal materials in ethanol with a concentration of 70% for 0.5 hours, heat and reflux for 2 hours, filter, Collect the filtrate, add 70% ethanol with 6 times the weight of the medicinal material to the filter residue, heat and reflux for extraction for 1.5 hours, filter, collect the filtrate, combine the two filtrates, concentrate, bake the liquid extract in an oven at 80°C until completely dry, and then pulverize into fine powder (through 80 mesh sieve).

[0045] (3) Take 65 parts of the above-mentioned fine powder, add 15 parts of starc...

Embodiment 3

[0047] (1) Weigh each API according to the following weight ratio (take ten times the ratio of API as an example):

[0048] 600 parts of vine pear root,

[0049] Iwami wears 300 copies,

[0050] 300 copies of Scutellaria barbata,

[0051] Hedyotis diffusa 300 parts,

[0052] 300 parts of knotweed.

[0053] (2) The above weight ratio of Tengligen, Shi Jianchuan, Scutellaria barbata, Hedyotis diffusa, Polygonum cuspidatum plus 8 times the weight of the medicinal materials, soaked in water for 0.5 hours, heated and refluxed for 2 hours, filtered, collected the filtrate, and added the filter residue 6 times the weight of medicinal materials in water, heat and reflux to extract for 1.5 hours, filter, collect the filtrate, combine the two filtrates, concentrate, bake the liquid extract in an oven at 80°C until it is completely dry, and then crush it into a fine powder (through a 80-mesh sieve) .

[0054] (3) Take 75 parts of the above-mentioned fine powder, add 5 parts of starc...

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Abstract

The invention discloses a compound Chinese actinidia root Chinese medicinal composition and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines. The Chinese medicinal composition is characterized by comprising the following traditional Chinese medicines in parts by weight: 40-80 parts of Chinese actinidia root, 20-40 parts of salvia chinensis, 20-40 parts of herba scutellariae barbatae, 20-40 parts of herba oldenlandiae and 20-40 parts of giant knotweed. The compound Chinese actinidia root Chinese medicinal composition has remarkable proliferation inhibition effects on various cancer cells such as a hepatoma cell line Hep-G2, a lung cancer cell line NCI-H460, a gastric cancer cell line MGC-803, a breast cancer cell line MCF-7, a colon cancer cell line HCT-116 and the like, and can be used for reducing physical and psychological pains of a cancer patient in the chemo-treatment process and solving the problems of difficult and expensive administration.

Description

Technical field: [0001] The invention belongs to the technical field of compound traditional Chinese medicines, and in particular relates to a compound rattan pear root traditional Chinese medicine composition, a preparation method and an application thereof. Background technique: [0002] Cancer is a difficult problem of global medical attention. All countries attach great importance to it, and various preventive and therapeutic measures are being intensively studied. The latest statistics show that the incidence of cancer is on the rise. China is a country with a large population, and it is also a country with a high incidence of cancer. The annual cost of cancer diagnosis and treatment in the country reaches tens of billions. At present, most chemotherapeutic drugs used in domestic cancer clinical treatment have the problems of poor targeting, high toxicity and side effects, and easy to cause drug resistance. A few drugs with better curative effect mainly rely on imports...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P35/00
Inventor 刘宇皞缪建荣赵成建王洪锋
Owner ZHEJIANG SIXIAN PHARMA
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