Agent having anti-helicobacter pylori activity

An anti-Helicobacter pylori and Helicobacter pylori technology, applied in the directions of antibacterial drugs, antitumor drugs, plant/algae/fungus/moss components, etc., can solve problems such as safety or recurrence, and achieve high safety , excellent thermal stability, excellent proliferation inhibition effect

Inactive Publication Date: 2011-10-12
JAPAN ROYAL JELLY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the treatment with these conventional antibiotics, there are often problems of safety and recurrence during long-term administration, so the development of effective and safe drugs is desired.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of extract

[0036] As plants of the Lamiaceae family, sylvestris, Elsholtzia and Perilla are used. Elsholtzia regulosa (Elsholtzia regulosa) is harvested from large peaches in Yunnan Province, China, and uses its dried plants (including flower spikes). Elsholtzia ciliata (Elsholtzia ciliata) uses finely chopped and dried all-flower-period commercial products (Hyakuen-Kanfang Pharmaceutical Bureau, Neyagawa City). Perilla frutescens viridis is used after drying the commercially available flower spikes and leaves.

[0037] The extraction was performed as follows: with respect to 1 g of the dry powder obtained by grinding the dried grass body in a mortar, 30 ml of the extraction solvent was used, and the mixture was stirred overnight at 4°C. As the extraction solvent, PBS, 50% ethanol, and 100% methanol were used. It was centrifuged at 4,000 rpm for 30 minutes, and the supernatant was collected. The sample extracted with 50% ethanol or 100% methanol u...

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PUM

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Abstract

Disclosed is an agent having an anti-Helicobacter pylori activity. The agent is effective for the treatment, prevention or amelioration of diseases associated with Helicobacter pylori. The agent comprises an extract from a plant belonging to the family Lamiaceae, particularly an extract from a plant Elsholtzia ciliata, Perilla frutescens viridis or Elsholtzia regulosa, as an active ingredient. The agent has excellent heat stability, and can achieve the eradication effect within a short period.

Description

Technical field [0001] The present invention relates to an anti-Helicobacter pylori active agent capable of effectively sterilizing and eliminating Helicobacter pylori related to the occurrence of peptic ulcer. Background technique [0002] Helicobacter pylori (hereinafter also referred to as Helicobacter pylori) is a gram-negative bacillus (spirillum) that has several terminal flagella. Since it moves by rotating the flagella, it is named Spirobacterium (rotating bacteria). In addition, it is also characterized by being able to survive in a strongly acidic environment like the human stomach, and as its name implies, it mainly infects the pylorus of the stomach. [0003] The human infection is oral infection. For Japanese people, it was previously speculated that infection through well water was the main infection route. Therefore, although the infection rate is low among young people who grew up in the age when water supply facilities were developed, it is pointed out that the i...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/53A23L1/30A61K36/00A61P1/04A61P31/04A61P35/00
CPCA23V2002/00A61K36/53A61K36/535A23L33/105A61P1/04A61P31/04A61P35/00A23V2250/21
Inventor佐藤良也当真弘岩崎公典山口喜久二
OwnerJAPAN ROYAL JELLY