Croton Processing Method for Treating Tuberculosis

Abstract

The invention relates to a processing method of croton for treating tuberculosis, in particular to a high-temperature processing and attenuation method for traditional Chinese medicine croton and action thereof on treatment of the tuberculosis. The croton is processed through three methods of high-temperature frying, high-temperature roasting and microwave heating to obtain a croton processed product. In the processed croton, toxic protein is not detected, LD50 is obviously increased, the relative content of each component in croton oil is basically kept unchanged, and the croton oil content is relatively increased. After being combined with other traditional Chinese medicines to prepare pills, the processed croton has an obvious anti-tuberculosis bacillus effect in vivo and in vitro. Theprocessing method of the croton for treating the tuberculosis disclosed by the invention has the effects of reducing toxicity and enhancing therapeutic effect; and compared with the conventional croton processing methods of roasting, boiling, steaming and the like, the processing method has the advantages of prominent advantages.

Description

technical field [0001] The invention relates to a processing method of Chinese medicinal materials, in particular to a processing method of croton for treating tuberculosis. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis infection. Mycobacterium tuberculosis invades the lungs and causes tuberculosis, which has been an infectious disease since ancient times and has become the number one infectious disease in the world in recent years. According to the report of the World Health Organization, nearly 1 / 3 of the people in the world have been infected with Mycobacterium tuberculosis, that is, 2 billion people have been infected with Mycobacterium tuberculosis, and about 3 million people die of tuberculosis every year. Tuberculosis has become one of the leading causes of death from infectious diseases in adults worldwide. my country is one of the 22 countries with a high burden of tuberculosis in the world, and the...

AI Technical Summary

Problems solved by technology

The above-mentioned Bawa pills are prepared by the traditional wax method, which is cumbersome and complicated for modern applications, and the controllability is poor, and the safety of medication cannot be guaranteed.

The 2010 edition of "Chinese Pharmacopoeia" adopts two methods of making croton cream. The croton oil removed by the pressing method is the active ingredient, which is a waste of resources. The pressing method uses slight heat, and the dilution method does not have a heating process, so the croton toxin cannot be removed. Toxicity will increase the risk of clinical safety medication

In the patent application number 200410038035.0, the croton is fried with beeswax until the kernels are burnt yellow, and then 60-80% ethanol is used to extract the croton kernels. This method cannot fully extract the active ingredient croton oil, resulting in a relatively large proportion of croton in the formulation. The use of croton in the patent will cause a waste of medicinal resources

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