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Anti-Foot-and-Mouth Disease Virus Monoclonal Antibody and Its Recognized Epitope and Application

A monoclonal antibody, foot-and-mouth disease virus technology, applied in the direction of antiviral agents, antiviral immunoglobulins, antibodies, etc., can solve the problem that the function and value of neutralizing monoclonal antibodies are unclear, and the nature and location of epitopes cannot be accurately determined. and other problems, to achieve the effect of good immune effect

Active Publication Date: 2011-12-14
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

These foreign studies use monoclonal antibody pressure screening or synthetic peptide scanning technology, which can only determine the amino acids or peptides related to the epitope, but cannot accurately determine the nature and position of the epitope
In my country, articles on neutralizing monoclonal antibodies to Asia1 and O-type FMDV have been published, but no research reports on neutralizing epitopes have been seen. Therefore, the functionality and value of these published neutralizing monoclonal antibodies are still unclear

Method used

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  • Anti-Foot-and-Mouth Disease Virus Monoclonal Antibody and Its Recognized Epitope and Application
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  • Anti-Foot-and-Mouth Disease Virus Monoclonal Antibody and Its Recognized Epitope and Application

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Embodiment Construction

[0040] The present invention will be further described below in conjunction with specific embodiments, and the advantages and characteristics of the present invention will become clearer along with the description. However, these embodiments are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0041] 1. Materials and methods

[0042] 1. Viruses, cells, strains and experimental animals

[0043] The foot-and-mouth disease virus strain Asia1 / YS / CHA / 05 belongs to the Asia1 type FMDV Jiangsu lineage, and the foot-and-mouth disease virus O / YS / CHA / 05 strain belongs to the O-type pan-sublineage; the suckling hamster kidney...

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Abstract

The invention discloses a monoclonal antibody resisting the foot and mouth disease virus, epitope identified by the monoclonal antibody, as well as application of the monoclonal antibody, and belongs to the field of prevention and control of the foot and mouth disease. The hybridoma cell line capable of excreting the neutralizing monoclonal antibody resisting O-type FMDV (foot and mouth disease virus) has a microbial preservation number of CGMCC (China General Microbiological Culture Collection Center) 2691. The invention also discloses amino acid sequences of linear neutralization epitope of O-type FMDV VP1 protein identified by the monoclonal antibody respectively. In-vitro neutralization tests and in-vivo animal protection tests prove that: the monoclonal antibody disclosed by the invention has excellent passive immune effect, can be applied to emergency prevention of the foot and mouth disease, and plays an excellent immune effect to the passive immunity of the foot and mouth disease.

Description

[0001] This case is a divisional application of an invention patent application with the application number "200810171257.8", the invention title "anti-foot-and-mouth disease virus monoclonal antibody and its recognized antigenic epitope and application", and the publication date is "June 9, 2010". document. technical field [0002] The present invention relates to monoclonal antibodies, in particular to neutralizing monoclonal antibodies against Asian type 1 FMDV and neutralizing monoclonal antibodies against O-type FMDV, and the present invention also relates to neutralizing epitopes recognized by the above-mentioned monoclonal antibodies, The present invention further relates to the application of the monoclonal antibody and the neutralizing epitope in preventing foot-and-mouth disease, belonging to the field of prevention and treatment of foot-and-mouth disease. Background technique [0003] Foot and mouth disease virus (Foot and mouth disease virus, FMDV) is a member of...

Claims

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Application Information

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IPC IPC(8): C12N5/20C07K16/10G01N33/577A61K39/42A61P31/14C12R1/91
Inventor 于力赵磊周国辉张春媛
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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