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A kind of Chuanxiong volatile oil dripping pill

A technology of Chuanxiong volatile oil and oil drop pills, which is applied in the field of medicine, can solve the problems of demanding storage conditions, affecting curative effect, instability, etc., and achieve the effects of maintaining stability, improving curative effect, and facilitating preservation

Inactive Publication Date: 2011-12-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ligusticolide is a typical representative of phthalide compounds, and its stability is relatively good in the volatile oil of Chuanxiong Rhizoma, but the volatile oil of Chuanxiong Rhizoma is very unstable in aqueous solution, easy to decompose, and affects the curative effect, and the existing oral liquid or injection of the volatile oil of Chuanxiong The storage conditions of the preparation are demanding [see Gao Lihong et al. Stability investigation of Chuanxiong extract and its effect on rabbit platelet aggregation. Pharmaceutical Services and Research, 2004; 4(3): 215-217]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Preparation of Rhizoma Chuanxiong Volatile Oil Dropping Pills

[0018] (1) Preparation of Rhizoma Chuanxiong volatile oil: take 10kg of Rhizoma Chuanxiong medicinal material (place of origin: Dujiangyan, Sichuan), crush it to about 40 meshes, add water to soak for 12 hours to make the medicinal material fully absorb water and swell, add 100kg of water to the volatile oil extractor, heat and reflux for 8 hours, and collect the volatile oil. Centrifuge the volatile oil at 4000 rpm for 10 minutes, discard the water layer; add excess anhydrous sodium sulfate to the volatile oil to absorb possible moisture, and filter under reduced pressure to remove sodium sulfate; Store in a refrigerator at 4°C away from light for later use;

[0019] (2) Preparation of dripping pills: mix 50 g of Rhizoma Chuanxiong volatile oil with 10 g of Tween-80, add in polyethylene glycol matrix (200 g of polyethylene glycol 6000, 40 g of polyethylene glycol 4000) melted at 80 ° C, Mix e...

Embodiment 2

[0034] Example 2 Preparation of Rhizoma Chuanxiong Volatile Oil Dropping Pills

[0035] (1) Preparation of volatile oil of Rhizoma Chuanxiong: Take 5kg of dried rhizome of Rhizoma Chuanxiong (origin: Dujiangyan, Sichuan), wash it, dry it at 30-40°C, crush it to about 20 meshes, and put it in a carbon dioxide fluid extraction device (Nantong Huaan Supercritical Extractor) Extract the volatile oil from Ligusticum chinensis, extraction temperature is 30°C, extraction pressure is 7.2Mpa, separation temperature is 50°C, separation pressure is 5Mpa, extraction time is 1.5 hours, carbon dioxide flow rate is 30L / hour, and the extract is filtered to obtain the volatile oil of Ligusticum chuanxiong, and the volatile oil is centrifuged at 5000 rpm for 10min , discard the water layer, then add anhydrous sodium sulfate to absorb the water, and filter under reduced pressure to remove sodium sulfate to obtain 150 g of brown-yellow volatile oil.

[0036](2) Preparation of dripping pills: Add ...

Embodiment 3

[0038] Example 3 Preparation of Rhizoma Chuanxiong Volatile Oil Dropping Pills

[0039] (1) Preparation of volatile oil of Rhizoma Chuanxiong: Take 20kg of Rhizoma Chuanxiong medicinal material (origin: Dujiangyan, Sichuan), crush it to about 40 meshes, add water to soak for 12 hours to make the medicinal material fully absorb water and swell, add 100kg of water to the volatile oil extractor, heat and reflux for 8 hours, and collect the volatile oil , the volatile oil was centrifuged at 4000 rpm for 10 minutes, and the water layer was discarded; an excessive amount of anhydrous sodium sulfate was added to the volatile oil to absorb the moisture that might exist, and the sodium sulfate was removed by filtration under reduced pressure; Store in a 4°C refrigerator away from light and store for later use;

[0040] (2) Preparation of dripping pills: Add 100 g of Chuanxiong volatile oil into polyethylene glycol matrix (400 g polyethylene glycol 6000) melted at 80°C, mix evenly, drip...

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Abstract

The invention relates to the technical field of medicine, and relates to a Chuanxiong volatile oil drop pill for treating cardiovascular and cerebrovascular diseases such as cerebral thrombosis, cerebral embolism, transient cerebral ischemia, coronary heart disease, hypertension, arteriosclerosis, and vascular vertigo. The invention adopts a steam distillation method or a subcritical fluid extraction method to prepare chuanxiong volatile oil, and fully removes water in the chuanxiong volatile oil; mixes the chuanxiong volatile oil with polyethylene glycol matrix, and adopts a dropping pill machine to produce chuanxiong volatile oil drop pills. The Chuanxiong volatile oil dripping pill prepared by the present invention does not contain water, so the Chuanxiong volatile oil is stable. Compared with the Chuanxiong volatile oil injection or oral liquid, it has good stability, high bioavailability, and is easy to store. It can effectively improve the effect of Chuanxiong volatile oil on ischemic brain. Efficacy of vascular disease.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a Chuanxiong volatile oil drop pill for treating cardiovascular and cerebrovascular diseases such as cerebral thrombosis, cerebral embolism, transient cerebral ischemia, coronary heart disease, hypertension, arteriosclerosis, and vascular vertigo. Background technique [0002] Chuanxiong (Ligusticum chuanxiong Hort.) is a traditional Chinese medicine, which has the effects of promoting blood circulation, removing stasis, promoting qi and relieving pain. "Compendium of Materia Medica" records that Chuanxiong "this medicine goes up and treats all diseases of the mind". "Medical Qiyuan" said that Chuanxiong "enriches blood and treats blood deficiency and headache". Acute occlusive cerebrovascular disease belongs to the category of "stroke" in Chinese medicine. There are many prescriptions for treating this disease in traditional Chinese medicine, many of which are formulated with Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K9/20A61K47/34A61P7/02A61P9/02A61P9/10A61P9/12
Inventor 朱全刚刘继勇高申叶丽华全山丛宋洪杰高丽红
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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