Barberry bark extractive and use of barberry bark extractive and barberry bark

An extract, the technology of barberry bark, applied in the field of barberry bark extract, can solve the problems that have not been reported yet, and achieve the effect of increasing insulin sensitivity, overcoming adverse reactions, and preventing fat formation

Inactive Publication Date: 2013-12-04
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is no relevant report on the use of barberry bark or its extracts for the preparation of PPARs and LXR α agonists

Method used

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  • Barberry bark extractive and use of barberry bark extractive and barberry bark
  • Barberry bark extractive and use of barberry bark extractive and barberry bark
  • Barberry bark extractive and use of barberry bark extractive and barberry bark

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 barberry bark extract of the present invention

[0031]Take medicinal powder barberry bark (dry bark of Gansu Berberis kansuensis Schneid.) and break into coarse powder, soak for 24 hours, add 70% ethanol 9 times the amount, percolate at a speed of 2ml / min.kg, and collect the percolate , concentrated and dried.

Embodiment 2

[0032] The preparation of embodiment 2 barberry bark extract of the present invention

[0033] Take medicinal powder barberry bark (the dry bark of Gansu Berberis kansuensis Schneid.) and crush it into a coarse powder, add 12 times the amount of 70% ethanol, reflux extraction twice, combine the filtrates, concentrate, and dry to obtain the final product.

Embodiment 3

[0034] The preparation of embodiment 3 barberry bark extract of the present invention

[0035] Take barberry skin (dried skin of Berberis kansuensis Schneid. in Gansu Province), remove impurities, cut into sections, add water about 6-10 cm above the surface of the medicine, heat it, keep it in a boiling state for 1-2 hours, pour out the boiling liquid , the residue was decocted according to the above method, the residue was discarded, and the residue was decocted once again. The decoction liquid was combined and allowed to stand for 12 hours to allow impurities to precipitate. The filtrate was concentrated and obtained. If the component content of the extract is determined, it may also be dried.

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PUM

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Abstract

The invention discloses a barberry bark extractive. The invention also discloses a new use of barberry bark and an extractive thereof. The barberry bark and the extractive thereof can activate PPAR Delta, PPAR Alpha and Lxr Alpha, improve the human body glucose and lipid metabolism and increase the insulin sensitivity and has the remarkable effects of reducing the blood sugar and the blood lipid; and meanwhile, the barberry bark and the extractive thereof also can partially resist PPAR Gamma, overcome the adverse effect of a simple PPAR Gamma activator, block the fat formation and avoid the weight gain, cholesterol level rise and other side effects generated by the existing insulin sensitizer (PPAR Gamma activator), thereby providing a new choice for clinically treating metabolic diseases.

Description

technical field [0001] The invention relates to a barberry bark extract and the use of the extract and barberry bark, belonging to the field of medicine. Background technique [0002] With the improvement of living standards and the degree of modernization, the acceleration of the pace of life, the change of dietary structure and living habits, the incidence of a series of chronic diseases such as diabetes, hyperlipidemia, hypertension, and metabolic syndrome has gradually increased. Studies have found that insulin resistance (Insulin Resistance, IR) is not only the basis of type 2 diabetes, but also the main thread running through hyperlipidemia, metabolic syndrome and other metabolic-related diseases. It is the link connecting them and the common cause of these diseases. Pathophysiological basis. [0003] At present, studies on metabolic diseases have found that peroxisome proliferator-activated receptors (PPARs) are closely related to insulin resistance. PPARS includes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/29A61P3/04A61P3/06A61P3/10A61P5/50A61P13/12A61K129/00
Inventor 赖先荣张艺孟宪丽
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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