Xianlinggubao extract, preparation containing same and preparation method thereof

A technology of fairy bone bao and extract, applied in the field of medical invention, can solve the problems of high viscosity of liquid medicine, difficulty in filtering, difficult extraction of active ingredients, etc., and achieve remarkable results

Active Publication Date: 2012-02-08
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The active ingredients of the above method are not easy to extract, and the content is low, which affects the curative effect of the medicine, and the viscosity of the medicine liquid is relatively high, making it difficult to filter

Method used

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  • Xianlinggubao extract, preparation containing same and preparation method thereof
  • Xianlinggubao extract, preparation containing same and preparation method thereof
  • Xianlinggubao extract, preparation containing same and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Xianling Gubao Capsules

[0076] 1. The composition of the compound recipe: Epimedium 1167g, Suspension 167g, Salvia miltiorrhiza 83g, Anemarrhena 83g, Psoralea 83g, Rehmannia glutinosa 83g.

[0077] 2. Preparation method:

[0078] 1) Decoction and extraction of Epimedium with water for 3 times, the first time adding water 20 times, the second time adding 15 times water, the third time adding water 15 times, each 2h, the extract was filtered, the filtrate was combined, and concentrated to 80 times under reduced pressure The relative density at ℃ is 1.02, centrifuge while still hot, the rotation speed is 2500rpm, centrifuge for 20min, the supernatant is poured out, the macroporous adsorption resin HP-20 type, the concentration of the sample solution is 0.5g / ml; the sample volume is 1g crude drug / ml resin; the adsorption rate is 8ml / min; the elution rate is 16ml / min; the water elution volume is 5 times the column volume, the eluent is pale yellow, and the wat...

Embodiment 2

[0090] Example 2: Xianling Gubao Granules

[0091]1. Composition: Epimedium 600g, Suspension 80g, Salvia miltiorrhiza 50g, Anemarrhena 50g, Psoralea 50g, Rehmannia glutinosa 50g.

[0092] 2. Preparation method

[0093] 1) Decoction and extraction of Epimedium with water for 3 times, the first time adding 30 times water, the second time adding 20 times water, the third time adding 20 times water, decocting for 3 hours each time, the extract was filtered, The filtrate was combined, concentrated to a relative density of 1.08 at 90°C, centrifuged while hot, the rotation speed was 2500rpm, and the time was 20min, and the supernatant was poured out. 0.5g / ml; the loading volume is 1g crude drug / ml resin; the adsorption rate is 8ml / min; the elution rate is 16ml / min; the water elution volume is 5 times the column volume, the eluent is pale yellow, and the water is discarded Eluent (check for leakage of icariin, epimedin C, and total flavonoids); elute with 4 times the column volume o...

Embodiment 3

[0101] Example 3: Xianling Gubao Tablets

[0102] 1. Compound composition: Epimedium 1500g, 200g continuum, 150g Salvia miltiorrhiza, 150g Anemarrhena, 150g psoraleae, and 150g Rehmannia glutinosa.

[0103] 2. Preparation method:

[0104] 1) Epimedium is boiled and extracted 3 times with water. The first time is 20 times of water, the second time is 15 times of water, and the third time is 15 times of water. Each time is boiled for 2 hours, the extract is filtered, the filtrate is combined, and concentrated into a The relative density is 1.02 when it reaches 80°C, centrifuge while hot, the speed is 2500rpm, the time is 20min, the supernatant is poured out, passed through HP-20 macroporous adsorption resin column, the concentration of the sample solution is 0.5g / ml; The amount is 1g crude drug / ml resin; the adsorption rate is 8ml / min; the elution rate is 16ml / min; the water elution volume is 5 times the column volume, the eluent is light yellow, and the water eluent is discard...

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Abstract

The invention relates to a xianlinggubao extract, a preparation containing the same and a preparation method thereof. The extract is prepared from the following traditional Chinese medicines in parts by weight: 600-1,500 parts of epimedium herb, 50-150 parts of red-rooted salvia root, 50-150 parts of malaytea scurfpea fruit, 80-200 parts of himalayan teasel root, 50-150 parts of common anemarrhena and 50-150 parts of rehmannia. Active ingredients of the extract include alcohol extracts of red-rooted salvia root and malaytea scurfpea fruit and water extracts of epimedium herb, himalayan teaselroot, common anemarrhena and rehmannia. The xianlinggubao extract provided by the invention has a good curative effect on osteoporosis, and has a better effect than extracts provided by the prior art.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to an extract of Xianling Gubao compound and a preparation method thereof. Background technique [0002] Osteoporosis is an absolute decrease in the total amount of bone tissue per unit volume, that is, bone mass, resulting in changes in bone structure and function, resulting in peripheral bone pain, postural deformation and other symptoms and prone to fractures. [0003] Osteoporosis is a very serious and potentially fatal disease. At present, there are hundreds of millions of people suffering from this disease in the world. In the advanced stage of the disease, the bone tissue will become extremely fragile, even if you cough or turn over in bed. Fractures are possible. According to the estimates of the American Osteoporosis Foundation, 2% of female patients die due to bone and hip fractures, and the cost of treatment is also quite high. In the United States alone, the annual med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P19/10
Inventor 王晓春杜守颖周宁李冬雪陈雯冯泽熹孙宜春曾香兰
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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