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Preparation method of andrographolide

A technology of andrographolide and andrographis paniculata, applied in the field of medicine, can solve the problems of low yield, achieve high transfer rate, reduce organic solvent residue, and produce safe and effective results

Active Publication Date: 2012-03-21
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] When the macroporous resin method is used for elution, ethanol eluates with different alcohol degrees contain andrographolide in varying degrees, and the eluate content of 80% ethanol is higher, but the yield is lower

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Get the medicinal material of Andrographis paniculata, use 90% ethanol for multi-stage continuous extraction (extract 3 cans), extract 2 times in each can, keep 4 times the amount of extraction solvent, and extract for 8 hours each time; collect the extract, add appropriate amount of water, adjust to ethanol The concentration is 50%, filter; the filtrate is heated to 70°C, add an appropriate amount of activated carbon, stir for 30min, and filter; the filtrate is concentrated at 70°C until cloudy, the concentrate is cooled, the supernatant is discarded, and the precipitate is collected; the precipitate is added with 0.3 times ethanol , stirred at 70°C, stood still, separated solid-liquid, and collected the solid; then added 0.3 times of ethanol, stirred, stood still, separated solid-liquid, and obtained coarse crystals; added 30 times of 90% ethanol solution to coarse crystals, and added an appropriate amount at 70°C Activated carbon, stirred for 30 minutes, filtered; the...

Embodiment 2

[0035] Get the Andrographis paniculata medicinal material, use 95% ethanol multi-stage continuous extraction (extract 4 cans), extract 2 times in each can, keep 5 times the amount of extraction solvent, extract 12 hours each time; collect the extract, add appropriate amount of water, adjust to ethanol The concentration is 60%, filter; the filtrate is heated to 60°C, add an appropriate amount of activated carbon, stir for 30min, and filter; the filtrate is concentrated at 60°C until cloudy, the concentrate is cooled, the supernatant is discarded, and the precipitate is collected; the precipitate is added with 1 times ethanol , stirring at 55°C, standing still, solid-liquid separation, and collecting the solid; then adding 0.3 times of ethanol, stirring, standing, and solid-liquid separation to obtain coarse crystals; adding 50 times of 95% ethanol solution to the coarse crystals, and adding an appropriate amount at 60°C Activated carbon, stirred for 30 minutes, filtered; the fil...

Embodiment 3

[0037] Take Andrographis paniculata, soak and extract 2 times with 4 times the amount of 75% ethanol, and extract for 12 hours each time; collect the extract, add an appropriate amount of water, adjust the ethanol concentration to 40%, and filter; heat the filtrate to 60 ° C, add 0.2% activated carbon, stirred for 30 minutes, filtered; the filtrate was concentrated at 60°C until turbid, the concentrated solution was cooled, the supernatant was discarded, and the precipitate was collected; the precipitate was added with 1 times ethanol, stirred, stood still, separated from the solid and liquid, and collected the solid; Then add 0.5 times of ethanol, stir, stand still, and separate solid and liquid to obtain coarse crystals; add 50 times of 90% ethanol solution to the coarse crystals, add 0.2% activated carbon at 60°C, stir for 30min, and filter; the filtrate is concentrated under reduced pressure at 60°C To turbidity, recrystallization, drying, that is.

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PUM

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Abstract

The invention provides a preparation method of andrographolide. The preparation method includes steps of extracting ethanol of common andrographis herb crude medicine, filtering, decolorizing by the aid of activated carbon, filtering again, concentrating cooling of a concentrated liquor, removing supernatant fluid, collecting deposit, washing the deposit by ethanol to obtain macro-crystal, dissolving the macro-crystal by ethanol, decolorizing the macro-crystal by the aid of activated carbon, filtering the macro-crystal, concentrating filtrate, recrystallizing and drying so that andrographolide is obtained. The transfer rate of andrographolide of the method is high, remained organic solvent is less, and a product is safer and effective.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of andrographolide. Background technique [0002] Andrographolide is a diterpene lactone compound extracted from the plant Andrographis paniculata of the family Acanthaceae. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. It has the functions of clearing away heat and detoxification, cooling blood and reducing swelling. [0003] Andrographolide has a special effect on bacterial and viral upper respiratory tract infections and dysentery, and is known as a natural antibiotic drug. At present, the andrographolide preparations approved by the State Food and Drug Administration mainly include tablets, capsules, and drop pills. [0004] There are many reports on the preparation and efficacy of andrographolide, such as: Chinese patent 200710142800.7, which describes a method of separating with resin after alcoh...

Claims

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Application Information

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IPC IPC(8): C07D307/60
Inventor 刘岩戚可人徐波李伟范开马继忠万晟
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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