Calcium folinate for injection and production technology for calcium folinate

A technology for calcium folinate and injection, which can be used in the fields of anti-toxic agents, freeze-dried delivery, metabolic diseases, etc. It can solve the problems of poor formability of calcium folinate freeze-dried powder injections, and achieve the effect of solving poor formability

Inactive Publication Date: 2012-05-02
HENAN FUREN HUAIQINGTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a calcium folinate freeze-dried powder for injection in order to avoid the disadvantages of the ab

Method used

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Embodiment Construction

[0024] Calcium folinate for injection of the present invention is composed of anhydrous calcium folinate, mannitol, medicinal charcoal and fresh water for injection; wherein, every 1000ml of calcium folinate for injection contains 25g of anhydrous calcium folinate, 35g of mannitol and Medicinal charcoal 3g, the rest are fresh water for injection.

[0025] The production process of the present invention is: making water, washing out bottles, washing, removing rubber stoppers, preparing, filling and freezing.

[0026] 1. Water production

[0027] Make purified water and water for injection.

[0028] 2. Wash out bottle

[0029] The bottles were ultrasonically cleaned and autoclaved.

[0030] 3. Washing and removing rubber stoppers

[0031] Operate the rubber stopper cleaning machine according to the standard operation and maintenance procedures of the automatic wet ultrasonic rubber stopper cleaning machine.

[0032] Feeding: Start the rubber stopper cleaning machine, the ma...

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Abstract

The invention provides calcium folinate for injection and a preparation method for the calcium folinate. The calcium folinate for injection consists of anhydrous calcium folinate, mannitol, medicinal carbon and fresh water for injection. The preparation method comprises the following steps of: dissolving the mannitol and the calcium folinate into the water for injection, adding the medicinal carbon, boiling, standing and decarburizing; and regulating the pH value by using sodium hydroxide, filtering through a cylindrical filter, and thus obtaining the calcium folinate for injection, wherein the prepared calcium folinate for injection is prepared into freeze-dried powder injection by pre-freezing, subliming and drying. Because the mannitol serving as an excipient is added in the calcium folinate for injection, the prepared freeze-dried powder injection is a loose and porous block and is quickly dissolved into the water and the solution is clear, the defect of poor forming property of the calcium folinate freeze-dried powder injection in the prior art is overcome.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and provides calcium folinate for injection and a preparation method thereof. Background technique [0002] Calcium folinate is the calcium salt of the formylated derivative of tetrahydrofolate, which is the activated form of folic acid in the body. It is often used as an antidote for the overdose of aminopterin and methotrexate, and has the effect of counteracting the toxicity of folic acid antagonists (such as methotrexate, pyrimethamine, and trimethoprim). As an anti-anemia drug, it can be used for megaloblastic anemia and leukopenia, and can treat megaloblastic anemia caused by folic acid deficiency, and promote the differentiation, maturation and release of bone marrow hematopoietic cells; it can also be combined with 5-fluorouracil Medication can improve the anti-tumor effect of 5-fluorouracil, and it is an adjuvant anti-tumor drug. [0003] Calcium folinate injection is mainly u...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/519A61K47/26A61P39/02A61P7/06A61P3/02A61P35/00
Inventor 白宗锋陈水库武东亮
Owner HENAN FUREN HUAIQINGTANG PHARMA
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