Gas chromatography fingerprint detection method for blood-nourishing brain-refreshing grain

A technology of Yangxuexuenao granule and fingerprint, which is applied in the detection field of Yangxuexuenao granule to achieve the effect of optimized chromatographic conditions, good repeatability and precise measurement results

Active Publication Date: 2012-05-09
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on the fingerprints of brain granules of nourishing blood serum at home and abroad.

Method used

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  • Gas chromatography fingerprint detection method for blood-nourishing brain-refreshing grain
  • Gas chromatography fingerprint detection method for blood-nourishing brain-refreshing grain
  • Gas chromatography fingerprint detection method for blood-nourishing brain-refreshing grain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1, detection method

[0044] Instruments and reagents

[0045] Aglient6890 gas chromatograph (with FID detector); Aglient6890-5973 GC-MS coupled instrument; DB-5MS quartz capillary column (30m × 0.25mm, 1μm; American Agilent company); Milli-Q ultrapure water system (France Millipore Company); 10 batches of finished products of Yangxue Xuenao Granules (batch numbers 080502, 080604, 080609, 080613, 080620, 080621, 080622, 080626, 080629, 080702, and sequentially marked as S1-S10) were produced by Tianjin Tasly Group Pharmaceutical Co., Ltd. Provided; all reagents used were of analytical grade.

[0046] Preparation of standard test solution

[0047] Select 10 batches of Yangxue Xuenao Granules with qualified quality as standard samples (provided by Tianjin Tasly Pharmaceutical Co., Ltd., and all indicators are qualified according to the requirements of the Pharmacopoeia), respectively accurately weigh 12g in a 250mL round bottom flask, add ultrapure water 100...

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Abstract

The invention provides a gas chromatography fingerprint detection method for blood-nourishing brain-refreshing grains, which comprises the following steps of: (1) preparing blood-nourishing brain-refreshing grain test sample soution: extracting the blood-nourishing brain-refreshing grain with a steam distillation method, and dissolving a volatile oil ingredient by ethyl acetate; and (2) injecting the volatile oil obtained in step (1) into a liquid chromatograph to measure, and obtaining the chromatogram map of the volatile oil. According to the self characteristics of the blood-nourishing brain-refreshing grain, the fingerprint of the blood-nourishing brain-refreshing grain is measured by the gas chromatography, an optimized chromatogram condition is found, a measured result is precise, and the receptivity and the stability are good.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a detection method of nourishing serum brain granules. Background technique [0002] Yangxue Xuenao Granules are refined from 11 traditional Chinese medicines including Angelica, Chuanxiong, Paeoniae Alba, Uncaria, Millae, Rehmannia, Cassia, Prunella, Asarum, Corydalis and Mother of Pearl, and are refined by modern preparation technology. The function of blood calming the liver, promoting blood circulation and dredging collaterals is used for headache, dizziness, irritability, insomnia and dreaminess caused by blood deficiency and hyperactivity of the liver. It is a traditional Chinese medicine variety under the national key protection. [0003] The formula and preparation method of Yangxue Xuenao Granules are all existing technologies, and are included in the national quality standard. According to this standard, Yangxue Xuenao Granules are first made from 11 medicinal material...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16G01N30/02A61P7/06A61P25/00A61P29/00A61P1/08A61P25/20A61K35/56A61K35/618
Inventor 高钧李文博佟玲倪倩
Owner TIANJIN TASLY PHARMA CO LTD
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