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MMB4 DMS nano suspension and preparation method and application thereof

A kind of nano-suspension, suspension technology, applied in the field of medicine

Pending Publication Date: 2020-12-22
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] MMB4 DMS is easily soluble in water, but it is unstable under the conditions of water, oxidation, strong acid and strong alkali, and it is easy to degrade to produce degraded substances, and the starting materials, intermediates and side reaction products introduced in its preparation all become Related substances that affect the quality of medicines, so they need to be controlled to ensure the quality and safety of medicines, and to achieve controllable quality of medicines

Method used

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  • MMB4 DMS nano suspension and preparation method and application thereof
  • MMB4 DMS nano suspension and preparation method and application thereof
  • MMB4 DMS nano suspension and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0090] Example 1 Preparation of MMB4 DMS nanosuspension

[0091] At room temperature, weigh 900g of cottonseed oil, slowly add 100g of MMB4 DMS, stir and mix; ultrasonically homogenize for 15min, ultrasonic frequency 10000rpm; pour the obtained mixture into a wet mill for grinding, temperature 28°C, initial speed 1500rpm , increase the rotation speed by 500rpm every 5 minutes until 3000rpm, and grind for 2h, that is to say. The particle size of MMB4 DMS nanoparticles is 215.8nm, the polydispersity index (PDI) is 0.282, and the viscosity of the preparation is 340mPa.s.

Embodiment 2

[0092] The preparation of embodiment 2 MMB4 DMS nanosuspension

[0093]At room temperature, 10 g of MMB4 DMS was added into 90 g of cottonseed oil under stirring at 500 rpm, and the stirring was continued for 10 min. Then the mixture was ultrasonically homogenized for 10 min at an ultrasonic frequency of 8000 rpm. Put the obtained mixture into the wet mill, put it into the wet mill, the temperature is 30°C, the initial speed is 1200rpm, and the speed is increased to 500rpm every 5 minutes until it reaches 3500rpm, and it is ground for 1.5h to obtain the final product.

[0094] The particle size of MMB4 DMS nanoparticles is 228.9nm, the polydispersity index (PDI) is 0.475, and the viscosity of the preparation is 320mPa.s.

Embodiment 3

[0103] Example 3 Preparation of MMB4 DMS nanosuspension

[0104] Weigh 27kg of cottonseed oil, slowly add 3kg of MMB4 DMS, stir and mix; ultrasonically homogenize for 10min, ultrasonic frequency 15000rpm; pour into a wet mill for grinding, temperature 30°C, initial speed 6m / s, increase the speed every 5 minutes 1m / s, until 11m / s, grind for 4h, that is.

[0105] The particle size of the prepared midazolam nanocrystals was 253.2nm, the polydispersity index (PDI) was 0.327, and the viscosity of the preparation was 345mPa.s.

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Abstract

The invention provides an MMB4 DMS nano suspension and a preparation method and application thereof. The nano suspension is composed of 1.0%-25.0% (w / w) of MMB4 DMS and a dispersion medium, wherein the viscosity of the nano suspension is 200-650 mPa.s, the polydispersity index (PDI) of nanocrystal particles of the nano suspension is 0.1-0.7, and the dispersion medium is oil. The preparation provided by the invention is proper in viscosity, not only cannot cause grinding difficulty due to an over-large viscosity, but also cannot cause sedimentation due to an over-small viscosity. The preparation process of the MMB4 DMS nano suspension is stable and suitable for the industrial production, and the nano suspension obtained by the process is free of particle aggregation and layering phenomena,and is good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a MMB4 DMS nano suspension, a preparation method thereof and an application thereof. Background technique [0002] In March 1995, a sarin poisoning incident occurred in Tokyo, Japan, killing 13 people and injuring about 6,300 people. It became the most serious terrorist attack in Japan after the end of World War II. Nerve agents are lethal agents that are highly toxic, highly effective, quick-killing, non-irritating, and have only a faint odor. Organophosphorus or organophosphate compounds strongly inhibit the activity of acetylcholinesterase in the brain, diaphragm, and blood, leading to severe dysfunction of the central and peripheral cholinergic nervous system, and causing systemic toxicity through absorption through the skin, mucous membranes, gastrointestinal tract, and lungs. Poisoning, and has the characteristics of strong toxicity and fast action. The main ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/44A61K31/444A61P39/02
CPCA61K9/10A61K47/44A61K31/444A61P39/02
Inventor 郑爱萍张洵李蒙张慧高静刘楠王增明高翔
Owner ACADEMY OF MILITARY MEDICAL SCI
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