A method for analyzing fingerprints of Jinghuaweikang capsules

A fingerprint, Kang capsule technology, applied in the field of medicine, to achieve good linearity, good repeatability and good stability.

Active Publication Date: 2017-11-21
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on the fingerprints of Jinghua Weikang Capsules at home and abroad.

Method used

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  • A method for analyzing fingerprints of Jinghuaweikang capsules
  • A method for analyzing fingerprints of Jinghuaweikang capsules
  • A method for analyzing fingerprints of Jinghuaweikang capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] (1) Preparation of reference substance solution: Take an appropriate amount of p-cymene reference substance, weigh it accurately, add ethyl acetate to make a solution containing about 0.5 mg of p-cymene per 1 mL, and obtain it.

[0103] (2) Preparation of the test solution: take an appropriate amount of the content of Jinghua Weikang capsules, weigh about 30 mg respectively, weigh them accurately, put them in a 5mL volumetric flask, add an appropriate amount of ethyl acetate to dissolve, and adjust the volume to the mark. Instantly.

[0104] (3) Take the test solution and analyze it by gas chromatography to obtain a fingerprint.

[0105] Chromatographic conditions:

[0106] Chromatographic column: the stationary phase is filled with 14% cyanopropyl-phenyl 86% dimethylpolysiloxane; column temperature: programmed temperature rise; inlet temperature: 250 °C; FID detector; temperature: 250 °C; Gas: Nitrogen.

[0107] The temperature programming conditions are:

[0108] ...

Embodiment 2

[0110] (1) Preparation of reference substance solution: Take an appropriate amount of p-cymene reference substance, weigh it accurately, add ethyl acetate to make a solution containing about 0.3 mg of p-cymene per 1 mL, and obtain it.

[0111] (2) Preparation of the test solution: take an appropriate amount of the contents of Jinghua Weikang capsules, weigh about 10 mg respectively, weigh them accurately, put them in a 5mL volumetric flask, add an appropriate amount of ethyl acetate to dissolve, and adjust the volume to the mark. Instantly.

[0112] (3) Take the test solution and analyze it by gas chromatography to obtain a fingerprint.

[0113] Chromatographic conditions:

[0114] Chromatographic column: stationary phase with 5% phenyl 95% dimethyl polysiloxane as filler, Agilent HP-5 (30m×0.32mm×0.25μm); column temperature: programmed temperature rise; inlet temperature: 150°C; FID detector; temperature: 300°C; carrier gas: nitrogen.

[0115] The temperature programming c...

Embodiment 3

[0118] (1) Preparation of reference substance solution: Take an appropriate amount of p-cymene reference substance, weigh it accurately, add ethyl acetate to make a solution containing about 0.7 mg of p-cymene per 1 mL, and obtain it.

[0119] (2) Preparation of the test solution: Take an appropriate amount of the contents of Jinghua Weikang capsules, weigh about 50 mg respectively, weigh them accurately, put them in a 5mL volumetric flask, add an appropriate amount of ethyl acetate to dissolve, and adjust the volume to the mark. Instantly.

[0120] (3) Take the test solution and analyze it by gas chromatography to obtain a fingerprint.

[0121] Chromatographic conditions:

[0122] Chromatographic column: cross-linked 50% phenyl-methyl polysiloxane as the stationary phase capillary column (column length is 30m, inner diameter is 0.32mm, film thickness is 0.25μm); column temperature: programmed temperature; inlet temperature : 200°C; FID detector; temperature: 300°C; carrier ...

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PUM

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Abstract

The invention provides a fingerprint analysis method of Jinghuaweikang capsules, which comprises preparation of a reference substance solution and a test solution, and then analyzing by gas chromatography to obtain a fingerprint. According to the characteristics of the Jinghua Weikang capsules, the analysis method of the present invention uses gas chromatography to measure the fingerprints of the Jinghua Weikang capsules, finds optimized chromatographic conditions, and makes the measurement results precise, repeatable and stable. The invention also provides a fingerprint of the Jinghuaweikang capsule.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a gas chromatography fingerprint detection method for Jinghua Weikang capsules. Background technique [0002] Jinghua Weikang Capsules are made from Nepeta chinensis and Shuituanhua, which have the functions of antacid, analgesia, inhibition of Helicobacter pylori and protection of gastric mucosa. This product has the effects of regulating qi and dispelling cold, clearing heat and removing blood stasis. It is suitable for epigastric distension, pain, belching, acid reflux, duodenal ulcer and other diseases. [0003] The formula and preparation method of Jinghua Weikang Capsules are all existing technologies. As an effective control method for the overall evaluation of the quality of traditional Chinese medicine in complex samples with multidimensional components, the fingerprint of traditional Chinese medicine is currently widely accepted at home and abroad to comprehensively e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 阚红玉葛丹丹孙玉侠曹凤兰
Owner TIANJIN TASLY PHARMA CO LTD
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