Method for combined preparation of high purity ursolic acid and high purity oleanolic acid from Ligustrum lucidum
A technology for oleanolic acid and combined preparation is applied in the field of natural medicines and achieves the effects of easy handling, low cost and simple method.
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[0010] Example 1:
[0011] Take 1Kg of Ligustrum lucidum dry product, add 8L of 5% sodium hydroxide aqueous solution, boil for 30 minutes, filter out the lye liquid while hot, wash the medicine residue with hot water, add the residue to 10L water and boil for 1.5 hours, pour out the boiling liquid, The residue was refluxed and extracted with 95% ethanol for 3 times, the amount of ethanol is 6L each time; combine the alcohol extracts, add 0.3% of the volume of the alcohol extracts with activated carbon, stir and decolorize at 50-60℃ for 1 hour; filter out the activated carbon and decolorize the alcohol The extract is adjusted to a pH of about 11 with 1mol / L sodium hydroxide aqueous solution. After standing for 12 hours, it is filtered to remove precipitation. The filtrate is concentrated under reduced pressure to about 1 / 3 of the volume before concentration (5L); a large amount of insoluble matter precipitates The insoluble matter is crude oleanolic acid, filtered, and the filtrat...
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[0016] Example 2:
[0017] Take 1Kg of Ligustrum lucidum dry product, add 8L of 5% sodium hydroxide aqueous solution, boil for 30 minutes, filter out the lye while hot, wash the medicine residue with hot water, add the residue to 10L of water and boil for 2 hours, pour out the water and boil The liquid and the residue were refluxed and extracted with 90% ethanol for 3 times, and the amount of ethanol for each time was 6L; combined the alcohol extracts, added 0.3% of the volume of the alcohol extracts with activated carbon, stirred and decolorized at 50-60°C for 1 hour; filtered off the activated carbon, Adjust the pH of the decolorized alcohol extract to about 11 with 1mol / L sodium hydroxide aqueous solution, let it stand for 12 hours and then filter to remove precipitation. The filtrate is concentrated under reduced pressure to about 1 / 3 of the volume before concentration (5L); there is a large amount of insoluble The insoluble matter is the crude oleanolic acid, filtered, and t...
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