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Spica Prunellae injection for animals and preparation method thereof

A technology of Prunella vulgaris and injection, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems that restrict the application, damage, and loss of Prunella vulgaris

Active Publication Date: 2012-07-11
JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the different chemical properties and extraction methods of the active ingredients in Prunella vulgaris, although the conventional water extraction and alcohol precipitation process is simple, there are many impurities, and the active ingredients cannot be efficiently and completely extracted and purified, or even lost or destroyed, which seriously restricts the extraction of Prunella vulgaris. Application in the field of veterinary medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: a Prunella vulgaris injection, which is composed of the following raw material ratios: 2000 g of Prunella vulgaris, 5 ml of Tween-80, and 5 ml of benzyl alcohol.

[0023] The above-mentioned Prunella vulgaris injection is prepared by the following steps:

[0024] A, get Prunella vulgaris 2000g and pulverize;

[0025] B, extraction and purification of rosmarinic acid:

[0026] (1) Ultrasonic extraction: Ultrasonic treatment at 300W power for 30min, suction filtration, place the filtrate in a 65°C constant temperature water bath for water bath extraction, where the extraction solvent is distilled water, Prunella vulgaris: distilled water = 1:15 (g / ml), extract Rear medicinal residue a is extracted with C process;

[0027] (2) Microfiltration to remove impurities: the extract is microfiltered with a 0.2 μm ceramic membrane to remove most of the pectin and protein;

[0028] (3) Extraction and purification: the filtrate was extracted twice with n-butanol...

Embodiment 2

[0035] Embodiment 2: A kind of Prunella vulgaris injection, is made up of following raw material ratio: Prunella vulgaris 2000g, Tween-80 5ml, benzyl alcohol 5ml

[0036] The above-mentioned Prunella vulgaris injection is prepared by the following steps:

[0037] A, get Prunella vulgaris 2000g and pulverize;

[0038] B, extraction and purification of rosmarinic acid:

[0039] (1) Ultrasonic extraction: Ultrasonic treatment at 200W power for 40 minutes, suction filtration, and the filtrate was extracted in a water bath with a constant temperature of 75°C. The extraction solvent was distilled water, Prunella vulgaris: distilled water = 1:25 (g / ml), extracted Rear medicinal residue a is extracted with C process;

[0040] (2) Microfiltration to remove impurities: the extract is microfiltered with a 0.2 μm ceramic membrane to remove most of the pectin and protein;

[0041] (3) Extraction and purification: the filtrate was extracted twice with n-butanol, and the extract was d...

Embodiment 3

[0048] Embodiment 3: a Prunella vulgaris injection, which consists of the following raw material ratios: 2000 g of Prunella vulgaris, 5 ml of Tween-80, and 5 ml of benzyl alcohol.

[0049] The above-mentioned Prunella vulgaris injection is prepared by the following steps:

[0050] A, get Prunella vulgaris 2000g and pulverize;

[0051] B, extraction and purification of rosmarinic acid:

[0052] (1) Ultrasonic extraction: Ultrasonic treatment at 400W power for 15 minutes, suction filtration, and the filtrate was placed in a 55°C constant temperature water bath for water bath extraction, where the extraction solvent was distilled water, Prunella vulgaris: distilled water = 1:10 (g / ml), extract Rear medicinal residue a is extracted with C process;

[0053] (2) Microfiltration to remove impurities: the extract is microfiltered with a 0.2 μm ceramic membrane to remove most of the pectin and protein;

[0054] (3) Extraction and purification: the filtrate was extracted twice wi...

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PUM

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Abstract

The invention relates to a Spica Prunellae injection for animals. A preparation method of the injection comprises the following steps: 1, carrying out ultrasonic treatment on crushed Spica Prunellae under a power of 200-400W for 15-40min, and carrying out microfiltration extraction to obtain a rosmarinic acid solution; and 2, adding 60-95% ethanol having a weight of 6-12 times the total weight of medicine residues obtained after ultrasonic extraction, carrying out reflux water extraction twice, mixing the obtained filtrates to obtain a filtrate, allowing the filtrate to go through an NKA macroporous resin, carrying out elution separation purifying by 50-60% ethanol, fully mixing the obtained eluate with the rosmarinic acid solution, adding Tween-80 and benzyl alcohol, uniformly mixing, adjusting the pH, adding 0.1-0.5% of active carbon, heating to 80DEG C under stirring, cooling, filtering, adding injection water to the obtained solution, embedding, and disinfecting. The injection has the following advantages: effective components with high purity and low toxicity have the efficacies of antibiosis, anti-inflammation, antivirus and the like, and the injection which has definite curative effects as a veterinary medicine antivirus product can substitute antibiotics, and can effectively improve medicine residual and medicine resistance problems.

Description

technical field [0001] The invention relates to a veterinary drug preparation, in particular to a Prunella vulgaris injection. Background technique [0002] Prunella vulgaris has the effects of clearing fire, improving eyesight, clearing liver, dispelling stagnation and reducing swelling, which are recorded in classical books. Described in "The Classic": "mainly cold and heat, scrofula, rat fistula, head sore, broken disease, scattered galls and stagnation of qi, swollen and damp feet". "Compendium of Materia Medica": "Lou Quanshan said: Prunella vulgaris can cure eye pearl pain, which is more effective at night; or use bitter cold medicine to reverse it, it is also magical. The eye pearl is connected with the eye root, and the liver system is also. It belongs to the meridian of Jueyin. If the night is severe and some bitter and cold medicine is counteracted, the night and cold are also yin. Xia Kui is endowed with pure yang qi and nourishes the blood of Jueyin, so it is li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/536A61K47/26A61K9/08A61P29/00A61P31/04
Inventor 晏永新
Owner JIANGXI NEW CENTURY MINXING ANIMAL HEALTH PROD CO LTD
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