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Micromolecular metabolite atlas as well as producing method and application thereof

A technology of small molecule metabolite and production method, which is applied in the field of blood small molecule metabolite map and its production, can solve the problem of lack of marker thyroid nodules, difficult identification of benign tumors and malignant tumors, and difficulty in determining the nature of thyroid nodules. question

Inactive Publication Date: 2012-07-11
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

Clinically, it is difficult to determine the nature of thyroid nodules. Even with pathological biopsy, sometimes thyroid adenomas and nodular hyperplasia, benign tumors and malignant tumors are not easy to clearly identify
At present, there are still no markers that can be used to judge benign and malignant thyroid nodules, and there are no related reports on the use of blood small molecule metabolite profiles to identify papillary thyroid cancer, benign thyroid nodules, or normal people

Method used

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  • Micromolecular metabolite atlas as well as producing method and application thereof
  • Micromolecular metabolite atlas as well as producing method and application thereof

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Embodiment Construction

[0023] The metabolite profiles that can be used for the differential diagnosis of benign and malignant thyroid nodules were screened from three groups of serum samples including normal subjects, simple thyroid nodules and papillary thyroid carcinoma.

[0024] 1. Serum sample collection and processing

[0025] The subjects of the study were mainly two groups of patients with simple thyroid nodules and papillary thyroid carcinoma who were first admitted to the hospital for pathological diagnosis after surgical resection due to thyroid nodules. Blood samples were drawn intravenously on an empty stomach in the early morning of the second day after the two groups were admitted to the hospital without any treatment. Another group of research objects is the blood samples of normal medical examiners whose age and sex are similar to those of the above two groups. Serum was prepared from the above blood samples by conventional methods.

[0026] Serum sample pretreatment: Serum samples...

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Abstract

The invention relates to the technical field of medical diagnostics, in particular to a blood micromolecular metabolite atlas for identifying papillary thyroid cancer, benign goiter or normal person, and a producing method thereof. The micromolecular metabolite comprises two blood metabolism markers, namely sphinganine 1-phosphate and hydroxybutyric acid which respectively have molecular weight of 453.2855 and 569.3481 as well as corresponding ions detected by mass spectroscopy of 454.2928 and 570.3547. Clinical experiment proves that the atlas has thyroid cancer judgment accuracy rate of 82% and non-cancer (benign goiter and normal person) judgment accuracy rate of 75.3%. The method provided by the invention has the advantages of high sensitivity and high flux, overcomes the defect that a non-invasive diagnosis method for diagnosing benign and malignant thyroid tubercle is lacking clinically at present, and is suitable for screening and assistant diagnosis of thyroid cancer.

Description

technical field [0001] The invention relates to the technical field of medical diagnostics, and relates to a blood small molecule metabolite map for distinguishing papillary thyroid cancer, benign goiter and normal people and a preparation method thereof. Background technique [0002] As an important technical means in the field of systems biology in the post-genome era, metabolomics has made great progress in recent years. Metabolomics focuses on the dynamic changes of all metabolites in cells, tissues, and organs after pathological stimulation or genetic modification, and systematically describes the occurrence and development of diseases through changes in metabolites from an overall perspective. All metabolites in body fluids can be used as indicators of the state of the living system, not only can reflect the results of various physiological adjustments, but also can be developed into a powerful tool for assisting clinical diagnosis. At present, corresponding diagnosti...

Claims

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Application Information

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IPC IPC(8): G01N30/72G01N30/02
Inventor 姚真真焦炳华施俊义苏东玮逄志骏马龙
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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