Total flavone extract of abelmoschus manihot and preparing method of total flavone extract

A technology of hollyhocks and extracts, which is applied in the directions of food preparation, pharmaceutical formulations, drug combinations, etc., can solve the problems of large dosage, low content of active ingredients, and low quality of hollyhocks.

Active Publication Date: 2012-07-25
JIANGSU SUZHONG PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through the preparation method of total flavonoids from hollyhock flowers of the present invention, the problem of low content and quality of active ingredients in the total flavonoids extract from hollyhock flowers is solved. In particular, the preparation method of the present invention is suitable for large-scale industrial production, and is easy to operate, easy to control, and suitable for industrialization. Using the preparation method of the present invention in production, the active ingredient ratio of the extract of hollyhock flower is better, the content is high, and the quality is high, which solves the problem of large dosage of hollyhock flower

Method used

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  • Total flavone extract of abelmoschus manihot and preparing method of total flavone extract
  • Total flavone extract of abelmoschus manihot and preparing method of total flavone extract
  • Total flavone extract of abelmoschus manihot and preparing method of total flavone extract

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Experimental program
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specific Embodiment approach

[0102] The hollyhock flower is the dried flower of Abelmoschus Manihot (L.) Medic, a plant of the genus Okra in the Malvaceae family.

[0103] The raw materials of hollyhock flower are provided by the hollyhock GAP planting base of Jiangsu Suzhong Pharmaceutical Group Co., Ltd., and other raw materials are commercially available, and meet the standards under the item "Solid hollyhock flower" of the 2010 edition of the Pharmacopoeia of the People's Republic of China.

Embodiment 1

[0104] Embodiment 1: the preparation of total flavonoids extract of hollyhock flower

[0105] 2000g of raw material medical material hollyhock flower of the present invention

[0106] Use 8 times the amount of 95% ethanol for the hollyhock flower, reflux extraction twice, each time for 1 hour, filter, combine the filtrate to recover the ethanol, concentrate the filtrate to a specific gravity of 1.20, and let the concentrate stand at 0°C-4°C for 24-48 hours, adjust the pH value to 6.0, and quickly dry the cold storage solution in a thin layer to obtain the crude extract of hollyhock flowers.

[0107] The total flavonoid content of the above-mentioned extract reaches 55.0% by weight percentage, wherein the total flavonoid extract contains: hyperoside 1.20%, isoquercitrin 1.50%, quercetin-3'-glucoside 1.00%, cotton bark Chlorin-3'-glucoside 0.9%. Take an appropriate amount of the above-mentioned crude extract, add quercetin-3'-glucoside and gossycetin-3'-glucoside to adjust to ...

Embodiment 2

[0108] Embodiment 2: the preparation of total flavonoids extract of hollyhock flower

[0109] 1000g of raw material medicinal material hollyhock flower of the present invention

[0110] Use 10 times the amount of 85% ethanol in the hollyhock flower, reflux extraction 3 times, each time for 2 hours, filter, combine the filtrate to recover the ethanol, concentrate the filtrate to a specific gravity of 1.35, pass the concentrated solution through a silica gel column, and use chloroform-methanol gradient washing After the extraction, the eluate is collected, concentrated, dried and pulverized to obtain the total flavonoids extract of marshmallow flowers. The volume ratio of chloroform-methanol can be followed by 20:80, 30:70, 40:60, 50:50, 60:40, 70:30, 80:20 to carry out gradient elution for 3 times of the column volume, and the collected chloroform-methanol Eluents in volume ratios of (30:70), (50:50) and (80:20).

[0111] The total flavonoid content of the above extract reach...

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Abstract

The invention discloses the weight ratio of cotton-3'-glucosidase, meletin-3'-glucosidase and isoquercitrin in total flavone extract of abelmoschus manihot. The total flavone extract of abelmoschus manihot has definite effective ingredients, more stable quality, more completed effective ingredients, better and more stable curative effect, safety and reliability, simple preparing process and low cost, is suitable for industrial production, has better effective ingredient ratio, high content and high quality and solves the problem of large dose of abelmoschus manihot.

Description

technical field [0001] The technology of the invention belongs to the field of traditional Chinese medicine pharmacy, and specifically relates to a marshmallow flower extract, a preparation and a preparation method thereof, and the marshmallow flower extract can be used for medicine, health products and food. Background technique [0002] Hollyhock flower is the dried flower of Abelmoschus Manihot (L.) Medic, a plant of the Malvaceae genus Abelmoschus Manihot (L.) Medic. The flower of hollyhock was first recorded in "Jiayou Materia Medica". It is widely distributed and rich in resources. Cold, slippery, non-toxic, it is mainly used for urination and stranguria, and for treating various malignant sores and pus that have not healed for a long time. In modern medicine, the main active ingredients of hollyhock flowers are flavonoids, and the current research on chemical components is also focused on total flavone of A (TFA) and its monomers in hollyhock flowers. Since the 1980s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A23L1/29A61P13/12A23L33/00
CPCA61K36/185A61K31/352A61K31/7034A61K2236/00A61P13/12
Inventor 唐仁茂徐柏颐唐海涛欧阳强闵文林周九兰
Owner JIANGSU SUZHONG PHARM GRP CO LTD
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