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Novel assay for the detection of amyloid beta peptides

An amyloid, sample technology, applied in the field of detection of Aβ in biological samples, can solve problems such as contradictions, unsuitable diagnostic methods, unsuitable for establishing reliable diagnostic assays, etc.

Inactive Publication Date: 2012-07-25
VIVORYON THERAPEUTICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, such methods are totally unsuitable for establishing reliable diagnostic assays
Using different dilutions in one study can lead to artefacts and ultimately completely wrong results
As long as there is no standardized protocol and method for plasma Aβ analysis, such studies will be contradictory and unsuitable for use as a diagnostic method in the future

Method used

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  • Novel assay for the detection of amyloid beta peptides
  • Novel assay for the detection of amyloid beta peptides
  • Novel assay for the detection of amyloid beta peptides

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Experimental program
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Embodiment

[0204] 1. Materials and Methods

[0205] 1.1 Patients and healthy controls

[0206] Patients with clinically diagnosed AD and healthy controls were recruited. In the pre-study examination, the neuropsychological functioning of all participants in this study was tested by several psychological tests (DemTect, Mini-Mental State Test, Clock Drawing Test).

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Abstract

The present invention pertains to a novel method for detection of A[beta] peptides, in particular in plasma, and to the use of A[beta] peptides for diagnosis of Alzheimer's disease.

Description

[0001] The present invention generally relates to the detection and diagnosis of Alzheimer's disease using Aβ(1-40) as a biomarker, and also relates to novel methods for detecting Aβ(1-40) in biological samples. Background technique [0002] Alzheimer's disease is the most common form of dementia and has a prevalence of approximately 65-70% of all dementia disorders. Due to increasing life expectancy, this disease has become a particular problem in highly developed industrialized countries such as Japan and China, as well as in the United States and Europe. The number of Alzheimer's patients was estimated from 2.4 x 10 in 2001 7 increased to 8.1×10 in 2040 7 (Ferri et al., 2005). Currently, the total cost of treatment and care for AD patients worldwide is about 2.5×10 per year 11 Dollar. [0003] The disease develops relatively slowly, and Alzheimer's disease typically persists for 10-12 years after the first symptoms occur. Currently, making a reliable and early diagnosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/536G01N33/577G01N33/68
CPCG01N33/6896G01N2333/4709G01N2800/2821
Inventor M·克兰施米特C·格特利希H-U·德穆特
Owner VIVORYON THERAPEUTICS NV