Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vitamin E self-emulsifying ointment

A vitamin and self-emulsification technology, applied in the field of medicine, can solve the problems of loss of biological activity, roughness, and low bioavailability of common preparations, and achieve the effect of good product curative effect, simple method, and rich raw materials

Inactive Publication Date: 2012-08-01
HENAN UNIV OF CHINESE MEDICINE
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The well-known vitamin E is a fat-soluble vitamin and an important antioxidant. It is soluble in organic solvents such as ethanol. Vitamin E can promote human metabolism, enhance body endurance, improve immunity, and protect biofilms from peroxidation. It plays the role of improving skin blood circulation, enhancing skin cell vitality and delaying aging. Without it, it will cause dry skin, rough skin, excessive aging and other adverse consequences.
In addition, vitamin E has many benefits to the human body. It has a good curative effect on skin care and beauty, and has a wide range of effects on skin diseases. Appropriate application of vitamin E can assist in the treatment of vitiligo, but vitamin E is unstable and easily affected by air. , light, heat, and metal ions catalyze and lose biological activity. In addition, vitamin E is highly fat-soluble and almost insoluble in water. The bioavailability of its common preparations is not high, and its application is limited. So how to improve the biological activity of vitamin E for external use? Utilization and enhancing its curative effect have always been technical problems to be solved in the medical field

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vitamin E self-emulsifying ointment
  • Vitamin E self-emulsifying ointment
  • Vitamin E self-emulsifying ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] In the specific implementation of the present invention, the vitamin E self-emulsifying ointment is prepared by mixing vitamin E as a drug and the self-emulsifying matrix as a drug carrier, and the content of vitamin E in 1 g of vitamin E self-emulsifying ointment is 20-300 mg. Described self-emulsifying matrix can be made by weight: oil phase 12%, emulsifier 48% and co-emulsifier 40%, and described oil phase is refining oil, glyceryl monostearate and stearyl alcohol, and its weight Ratio is 8: 2: 1, and described emulsifier is polysorbate 80 and polyoxyethylene hydrogenated castor oil (RH40), and its weight ratio is 2: 8, or is polysorbate 80 and polyoxyethylene castor oil ( EL), its weight ratio is 6: 4, and the described co-emulsifier is glycerin (glycerin), wherein, the oil phase is first placed in an 80°C constant temperature water bath to be heated and melted, and then the emulsifier and co-emulsifier are added successively. agent and vitamin E, dissolve and stir ...

Embodiment 2

[0027] In the specific implementation of the present invention, the vitamin E self-emulsifying ointment is prepared by mixing vitamin E as a drug and the self-emulsifying matrix as a drug carrier, and the content of vitamin E in 1 g of vitamin E self-emulsifying ointment is 20-300 mg. Described self-emulsifying base can be made by weight: oil phase 15%, emulsifier 50% and co-emulsifier 35%, and described oil phase is refining oil, glyceryl monostearate and stearyl alcohol, and its weight Ratio is 8: 2: 1, and described emulsifier is polysorbate 80 and polyoxyethylene hydrogenated castor oil (RH40), and its weight ratio is 2: 8, or is polysorbate 80 and polyoxyethylene castor oil ( EL), its weight ratio is 6: 4, and the described co-emulsifier is glycerin (glycerin), wherein, the oil phase is first placed in an 80°C constant temperature water bath to be heated and melted, and then the emulsifier and co-emulsifier are added successively. agent and vitamin E, dissolve and stir ev...

Embodiment 3

[0030] In the specific implementation of the present invention, the vitamin E self-emulsifying ointment is prepared by mixing vitamin E as a drug and the self-emulsifying matrix as a drug carrier, and the content of vitamin E in 1 g of vitamin E self-emulsifying ointment is 20-300 mg. Described self-emulsifying matrix can be made by weight: oil phase 18%, emulsifier 52% and co-emulsifier 30%, and described oil phase is refining oil, glyceryl monostearate and stearyl alcohol, and its weight Ratio is 8: 2: 1, and described emulsifier is polysorbate 80 and polyoxyethylene hydrogenated castor oil (RH40), and its weight ratio is 2: 8, or is polysorbate 80 and polyoxyethylene castor oil ( EL), its weight ratio is 6: 4, and the described co-emulsifier is glycerin (glycerin), wherein, the oil phase is first placed in an 80°C constant temperature water bath to be heated and melted, and then the emulsifier and co-emulsifier are added successively. agent and vitamin E, dissolve and stir ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a vitamin E self-emulsifying ointment, which can be used for effectively enhancing the bioavailability of external vitamin E and enhancing the curative effect. According to the technical scheme of the invention, the vitamin E self-emulsifying ointment is prepared by uniformly mixing vitamin E serving as a medicament and a self-emulsifying substrate serving as a medicamentcarrier; every gram of vitamin E self-emulsifying ointment contains 20-300mg of vitamin E; the self-emulsifying substrate is prepared from 12-20 percent by weight of an oil phase, 40-60 percent by weight of an emulsifier and 20-40 percent by weight of an auxiliary emulsifying agent; the oil phase consists of refined oil, glycerin monostearate and octadecanol in the weight ratio of 8:2:1; the emulsifier consists of polysorbate 80 and RH40 in the weight ratio of 2:8, or consists of polysorbate 80 and EL in the weight ratio of 6:4; and the auxiliary emulsifying agent is glycerol. The vitamin E self-emulsifying ointment is prepared by the following steps of: putting the oil phase into a constant-temperature water bath of 80 DEG C for heating and melting; adding the emulsifier, the auxiliary emulsifying agent and the vitamin E in sequence; dissolving and stirring uniformly; standing; and cooling for curing. The vitamin E self-emulsifying ointment has a good curative effect, and is an innovation of a medicament for externally treating skin diseases.

Description

1. Technical field [0001] The utility model relates to medicine, in particular to a vitamin E self-emulsifying ointment. 2. Background technology [0002] The well-known vitamin E is a fat-soluble vitamin and an important antioxidant. It is soluble in organic solvents such as ethanol. Vitamin E can promote human metabolism, enhance body endurance, improve immunity, and protect biofilms from peroxidation. It plays the role of improving skin blood circulation, enhancing skin cell vitality and delaying aging. Without it, it will cause dry, rough, excessive aging and other adverse consequences of skin. In addition, vitamin E has many benefits to the human body. It has a good curative effect on skin care and beauty, and has a wide range of effects on skin diseases. Appropriate application of vitamin E can assist in the treatment of vitiligo, but vitamin E is unstable and easily affected by air. , light, heat, and metal ions catalyze and lose biological activity. In addition, vit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/355A61K47/44A61P17/18A61P17/00
Inventor 魏玉刘雅敏杨艳娇何永超游志恒
Owner HENAN UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com