Kit for detection or assisted detection of tuberculous pleurisy

A tuberculous pleurisy and auxiliary detection technology, applied in the biological field, can solve the problems of affecting accuracy, increase, and small number of pleural effusion cells, and achieve the effect of less detection samples, high sensitivity, and high specificity

Active Publication Date: 2012-08-01
INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology

Therefore, some diagnostic methods using biomolecular markers have emerged one after another, such as adenosine deaminase (adenosine deaminase, ADA) and IFN-γ. Diagnostic of some value, but less than ideal disease specificity as both factors are also elevated in some other diseases
At the same time, studies have also shown that the high IFN-γ background affects the accuracy of the Mycobacterium tuberculos

Method used

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  • Kit for detection or assisted detection of tuberculous pleurisy
  • Kit for detection or assisted detection of tuberculous pleurisy
  • Kit for detection or assisted detection of tuberculous pleurisy

Examples

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Embodiment 1

[0019] Example 1. Application of the kit in detection or auxiliary detection of tuberculous pleurisy

[0020] The invention takes the isolated pleural effusion as the detection object, utilizes a group of immunological molecular markers, and uses a multi-factor microsphere detection technology to specifically identify tuberculous pleurisy.

[0021] 1. Kits and devices for detecting the expression of immune factors to detect the expression level of immune molecules

[0022] The test kits for detection or auxiliary detection of tuberculous pleurisy include test kits and devices for detecting the expression of immune factors, and the test kits for detecting the expression of the above immune factors are Human Cytokine / Chemokine Panel I kit, Human Cytokine / Chemokine Panel II kit and Human Cytokine / Chemokine Panel III kit; the above-mentioned device for detecting the expression of immune factors is a multifunctional liquid phase chip analyzer.

[0023] Samples: Collect isolated pl...

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PUM

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Abstract

The invention discloses a kit for detection or assisted detection of tuberculous pleurisy. The kit comprises a device for detecting the expression amount of an immune factor, wherein the immune factor comprises (1) IL-6, IL-13, G-CSF, CCL1, CCL21, IP-10 (CXCL10), CCL8 (MCP-2), CXCL9 (MIG) and CXCL12 (SDF-1); or (2) at least one of IL-6, IL-13, G-CSF, CCL1, CCL21, IP-10 (CXCL10), CCL8 (MCP-2), CXCL9 (MIG) and CXCL12 (SDF-1). Experiments prove that a method for specifically identifying tuberculous pleurisy by taking hydrothorax as a detection object, utilizing a group of immunologic molecular marker, and adopting a multiple-factor microsphere detection technique is developed, and the purposes of improving the disease diagnosis accuracy rate, scientifically judging the state of illness and the like are realized by a multiple-factor combination manner.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a kit for detecting or assisting in detecting tuberculous pleurisy. Background technique [0002] Tuberculosis is an infectious disease that seriously endangers people's health and the national economy. Nearly one-third of the world's population is infected with Mycobacterium tuberculosis. Tuberculous pleurisy is an important cause of pleural effusion in high-incidence areas of tuberculosis. The most reliable diagnosis of tuberculous pleurisy is the presence of Mycobacterium tuberculosis or the presence of granulomas of pleural tissue by biopsy. However, the number of Mycobacterium tuberculosis in pleural effusion is usually very small, and the detection sensitivity of acid-fast staining is extremely low, and tissue sectioning is an invasive diagnostic method, so there are limitations in clinical operations. Therefore, some diagnostic methods using biomolecular markers have emerged ...

Claims

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Application Information

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IPC IPC(8): G01N33/68
Inventor 刘海鹰于杨张艳金奇
Owner INST OF PATHOGEN BIOLOGY CHINESE ACADEMY OF MEDICAL SCI
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