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Human sperm specific transfer factor oral preparation and preparation process thereof

A technology of transfer factor and oral preparations, which is applied in the field of human sperm-specific transfer factor oral preparations and its preparation, can solve the problems of weak immunogenicity and short duration, and achieve appropriate immunization time, obvious effect, potential social value and Effect of Market Application Prospects

Inactive Publication Date: 2012-08-08
周建伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are contraceptive vaccines against antigens such as P18, LDH-C4, SPRASA, rSMP-B, CABYR, E-3, TSA-1, etc., but no matter which vaccine, it has an obvious shortcoming in summary, That is, the immunogenicity is weak, the duration is short, and continuous injections are required to maintain the antibody concentration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] The oral preparation of human sperm specific transfer factor of the present invention and its preparation process, specific examples are as follows:

[0029] 1. Preparation of Immunogen

[0030] Sperm from healthy people were taken, washed 3 times with sterile normal saline, prepared into a suspension with a concentration of 4.0×109 / ml, crushed completely with an ultrasonic cell disruptor at -4°C, and stored in a -20°C refrigerator for later use .

[0031] 2. Immunization of Animals

[0032] (1) Observation and detection before immunization

[0033] Three days before the immunization, the five white rabbits were all in good spirits, eating normally, and had no diarrhea; the venous blood was drawn, and the Brucella antibody was detected by the test tube agglutination method, and the titers were all less than 1:80.

[0034] (2) Immunization of white rabbits

[0035] White rabbits were immunized with the prepared human sperm antigen suspension, once a week, and the imm...

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Abstract

The invention discloses a human sperm specific transfer factor oral preparation and a preparation process thereof. The process mainly comprises the following steps of: preparing an immunogen; immunizing in an animal; and preparing a human sperm specific transfer factor, and the like. The oral preparation has the functions of transferring cell immune information, mediating a cell immune reaction, and specifically inhibiting and killing human sperms, and has the function of enhancing non-specific immunity; the oral preparation does not cause anaphylaxis, is practical and safe, has a remarkable effect, and does not cause medicament resistance after use; and the product is taken orally without being limited by conditions, is convenient, does not influence the biological activities of active ingredients, is a safe and effective preparation, and has potential social value and market application prospect.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an oral preparation of human sperm specific transfer factor and a preparation process thereof. Background technique [0002] With the continuous growth of population, many countries have formulated and promulgated family planning policies suitable for their own national conditions to control the growth rate of population. Under this background, birth control or contraception has become one of the hot topics of people's research. Traditional measures are rejected and opposed by people due to many disadvantages, such as the contraceptive ring is easy to fall off, the human body is damaged by ligation, the contraceptive pill has side effects, and the condom affects the sensation. Therefore, research on a non-damaging, reversible contraceptive product has become an urgent need for contemporary people, and the concept of immune contraception has emerged, and has quickly become a resea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K39/39A61P15/18A61K35/26
Inventor 周建伟孔翠
Owner 周建伟
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