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Method for extracting total saponins from bark of acanthopanax brachypus harms

A short-handled Wujia and extraction method technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of easy destruction of active ingredients, difficult on-line detection, and large amount of solvent, and can achieve the extraction time. The effect of shortening, reducing the extraction cost and reducing environmental pollution

Inactive Publication Date: 2012-09-19
EASTERN GANSU UNIVERSITY
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Problems solved by technology

[0002] At present, organic solvents are mainly used as extraction solvents at home and abroad, and techniques such as solvent immersion, Soxhlet extraction, heating reflux, ultrasonic-assisted extraction and microwave-assisted extraction are used to extract the active ingredients in natural products, but these techniques have different degrees of extraction. Long time, large amount of solvent, high toxicity, low extraction rate, easy destruction of active ingredients, and difficulty in online detection etc., greatly restrict the application of these technologies in the extraction of active ingredients of natural products

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  • Method for extracting total saponins from bark of acanthopanax brachypus harms
  • Method for extracting total saponins from bark of acanthopanax brachypus harms
  • Method for extracting total saponins from bark of acanthopanax brachypus harms

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Embodiment Construction

[0022] Extraction of saponins: in figure 1 In the process, the dry bark of Acanthopanax scutellariae was crushed to make a sample (11), and a certain mass of sample was weighed and put into an extraction tube (6) with an inner diameter of 50 mm and a length of 150 mm, and the upper and lower parts of the sample were filled with an appropriate amount of glass Cotton (7), put the extraction tube into the cavity of the microwave oven (1), and insert the ultrasonic probe (5) connected to the ultrasonic generator (2) through the wire (8) into the middle of the sample in the extraction tube. Prepare a certain volume of 1.5mol / L [Bmim]Br / H with a solid-to-liquid ratio of 1:30g / mL 2 The extraction solvent (12) of O, and the extraction solvent is pumped into the extraction tube by the peristaltic pump (4) and the infusion tube (10), and the microwave oven and the ultrasonic generator are turned on at the same time, and the solvent flow rate is adjusted to be 3mL / min, and the microwave ...

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Abstract

The invention relates to a method for extracting total saponins from bark of acanthopanax brachypus harms, and belongs to the field of extraction of active ingredients of natural products. The process flow is that the bark of acanthopanax brachypus harms is taken as raw materials, the mixed solvent of [Bmin]Br and water is taken as extraction solvent, continuous flowing extraction is performed through ultrasonic-microwave collaborative solvent, extraction process is detected through an IR detector, and filter liquor is deposited and centrifuged to obtain clear extracting solution; and the extracting solution is degreased through diethyl ether and is subjected to macroporous absorption resin column chromatography, so that 70% of ethanolic elution is collected, discolored through activated carbon, and impurities are removed through aluminum oxide so as to obtain total saponins. After analysis, the extraction rate achieves more than 8.56%, the content of the total saponins achieves more than 92.53%, and is higher than that of the total saponins obtained by other methods. The method has the advantages of normal pressure extraction, simple process, quickness and simplicity in operation, energy conservation and environmental friendliness and high selectivity, and can perform on-line detection to the extraction process; the saponin is not easy to denature, and does not need to be filtered and separated after extraction; and the extraction rate and purity of the total saponins are high, and the industrialized production can be facilitated.

Description

technical field [0001] The invention relates to the field of extracting active ingredients of natural products, in particular to a method for extracting total saponins from the stem bark of Acanthopanax brachycarpa. Background technique [0002] At present, organic solvents are mainly used as extraction solvents at home and abroad, and techniques such as solvent immersion, Soxhlet extraction, heating reflux, ultrasonic-assisted extraction and microwave-assisted extraction are used to extract the active ingredients in natural products, but these techniques have different degrees of extraction. Long time, large amount of solvent, high toxicity, low extraction rate, easy destruction of active ingredients, and difficulty in online detection greatly restrict the application of these technologies in the extraction of active ingredients of natural products. Ionic liquid is a green and environment-friendly solvent with high polarizability, strong microwave absorption and heat conver...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P29/00A61P35/00A61P25/00A61P31/12A61P3/06A61P3/10A61P37/02A61K129/00
Inventor 胡浩斌郑旭东何贵杰
Owner EASTERN GANSU UNIVERSITY
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