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Preparation method of indigowoad root and indigowoad leaf particles used for livestock and poultry

A granule, livestock and poultry technology, which is applied in the field of preparation of isai granules for livestock and poultry, can solve the problems of difficult operation in the post-production process, large loss of active ingredients, and violation of GMP, so as to save power and energy, facilitate leaching, and obtain ointment rate-enhancing effect

Active Publication Date: 2014-09-10
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently commonly used methods for preparing Banqing granules include traditional water-alcohol extraction, wet granulation, etc., which have many disadvantages, such as large loss of active ingredients, low content, difficult operation of post-production process, long production cycle, serious pollution in the production process, violation of GMP requirements, etc.

Method used

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  • Preparation method of indigowoad root and indigowoad leaf particles used for livestock and poultry
  • Preparation method of indigowoad root and indigowoad leaf particles used for livestock and poultry

Examples

Experimental program
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Effect test

Embodiment 1

[0019] The isatid granules for livestock and poultry in this embodiment are prepared from 40 parts of Radix isatidis, 60 parts of Folium Isatidis, 10 parts of anhydrous glucose, and 50 parts of cyclodextrin as main raw materials. The specific preparation method is as follows:

[0020] 1) Take 40 parts of Radix Isatidis and 60 parts of Folium Folium, chop them up and place them in the extraction tank to form a medicinal material layer, add water 8 times the total weight of Radix Isatidis and Folium Folium, submerge the medicinal material layer for 2 hours, and then adjust the work of the extraction tank The temperature is 60°C for extraction. During the extraction process, part of the extract is extracted from the bottom of the extraction tank for concentration under reduced pressure. The concentration temperature is 50°C. After condensation, the steam generated by the concentration is returned to the extraction tank as a new solvent for percolation and extraction of the medicina...

Embodiment 2

[0028] The isatid granules for livestock and poultry in this example are prepared from 60 parts of Radix isatidis, 90 parts of Folium Isatidis, 20 parts of anhydrous glucose, and 60 parts of maltodextrin as the main raw materials. The specific preparation method is as follows:

[0029] 1) Take 60 parts of Radix Isatidis and 90 parts of Folium Folium, chop them up and place them in the extraction tank to form a medicinal material layer, add water 8 times the total weight of Radix Isatidis and Folium Folium to submerge the medicinal material layer for 2 hours, and then adjust the work of the extraction tank The temperature is 70°C for extraction. During the extraction process, part of the extract is extracted from the bottom of the extraction tank for concentration under reduced pressure. The concentration temperature is 60°C. After condensation, the steam generated by the concentration is returned to the extraction tank as a new solvent for percolation and extraction of the medic...

Embodiment 3

[0034] The isatid granules for livestock and poultry in this example are prepared from 80 parts of Radix isatidis, 70 parts of Folium Isatidis, 10 parts of anhydrous glucose, and 70 parts of maltodextrin as the main raw materials. The specific preparation method is as follows:

[0035]1) Take 80 parts of Radix Isatidis and 70 parts of Folium Folium, chop them and put them in the extraction tank to form a medicinal material layer, add water 10 times the total weight of Radix Isatidis and Folium Folium to submerge the medicinal material layer for 2.5 hours, and then adjust the work of the extraction tank The temperature is 80°C for extraction. During the extraction process, part of the extract is extracted from the bottom of the extraction tank for concentration under reduced pressure. The concentration temperature is 70°C. After condensation, the steam generated by the concentration is returned to the extraction tank as a new solvent for percolation and extraction of the medicina...

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Abstract

The invention discloses a preparation method of indigowoad root and indigowoad leaf particles used for livestock and poultry. First, indigowoad root and indigowoad leaf are placed in an extraction tank, such that a medicine material layer is formed; the materials are soaked by using water; the working temperature of the extraction tank is regulated to 60-80 DEG C, and extraction is carried out; during the extraction process, a part of the extraction solution is fetched from the bottom of the extraction tank, and is subjected to vacuum concentration, wherein the concentration temperature is 50-70 DEG C; vapor generated by concentration is condensed and adopted as a novel solvent, and is delivered back to the extraction tank for carrying out percolation extraction upon the medicine material layer; the steps are repeated for 2-3h, and a fluid extract is obtained by concentration; anhydrous dextrose, maltodextrin or cyclodextrin, and the fluid extract are added into a spray-drying granulator for granulation, such that the indigowoad root and indigowoad leaf particles used for livestock and poultry are obtained. According to the preparation method of the indigowoad root and indigowoad leaf particles used for livestock and poultry, two processes which are the extraction and concentration of the indigowoad root and indigowoad leaf are carried out simultaneously, a pressurized and normal-pressure boiling process in a traditional extraction tank is changed, such that energy can be saved by 0.3-0.5 times, the dosage of a water solvent can be reduced by 0.5-1 time, a feeding amount is increased by 30-60%, an extract yield is increased by more than 10%, a storage process is reduced, and electric energy is saved by more than 30%.

Description

technical field [0001] The invention relates to a preparation method of banqing granules for livestock and poultry, belonging to the technical field of veterinary medicine. Background technique [0002] Traditional Chinese medicine granule (granula) is a new dosage form developed on the basis of decoction and syrup. It not only maintains the characteristics of fast absorption and rapid action of decoction, but also overcomes the inconvenience of decoction and large dosage. It is very suitable for clinical drug administration in modern and intensive farms. It has the advantages of good palatability, small dosage, rapid drug effect, controllable quality, good stability, and convenient storage, transportation and carrying. [0003] Banqing granule is a compound pure Chinese medicine preparation for livestock and poultry. It has the functions of clearing heat and detoxification, anti-inflammatory and anti-virus, and enhancing body immunity. Influenza virus, Newcastle disease, e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/195A61K36/704A61K36/315A61K36/855A61K47/40A61K47/36A61K47/26A61K9/16A61P31/12A61P31/04A61P31/20A61P31/14
Inventor 郭玉凡王喜平王佳伟杨晶张宁张旭
Owner ZHENGZHOU BARY ANIMAL PHARMA
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