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Method for discriminating nimodipine tablets

A nimodipine tablet, precise technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low precision, high repeatability, and inability to control product quality well, so as to achieve quality control and simple operation Effect

Inactive Publication Date: 2012-11-07
顾建光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing nimodipine tablet identification methods have problems such as low precision, high repeatability, and prone to deviation, and cannot control the quality of the product well.

Method used

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Examples

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Embodiment Construction

[0009] The present invention will be further described below in conjunction with the embodiments, but the present invention is by no means limited to the described embodiments.

[0010] Concrete steps of the present invention are as follows:

[0011] (1), take an appropriate amount of fine powder of nimodipine tablets, approximately equivalent to 45mg of nimodipine, add 6ml of ethanol, shake to dissolve the nimodipine, filter, take about 4ml of the continued filtrate, add fresh 8% sulfurous acid Add 4ml of ferric ammonium solution, add 2 drops of 2mol / L sulfuric acid solution and 2ml of 2mol / L potassium hydroxide solution, shake vigorously, the precipitate changes from gray-green to red-brown within 2 minutes;

[0012] (2), take 15 pieces of nimodipine tablets, accurately weigh, grind finely, accurately weigh an appropriate amount approximately equivalent to 15 mg of nimodipine, place it in a 50ml measuring bottle, add an appropriate amount of mobile phase, and sonicate for 20...

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Abstract

The invention relates to a method for discriminating a medicine, especially a method for discriminating nimodipine tablets. According to the method, a precipitate obtained from a chemical reaction of the nimodipine tablets turns from grayish green to umber, and the content of nimodipine is calculated according to peak area of an external standard method by chromatogram of the nimodipine tablets and a reference substance, so as to discriminate the quality of the nimodipine tablets. The discrimination method provided by the invention is simple and rapid to operate, and can be used to effectively control the quality of the product.

Description

technical field [0001] The invention relates to a method for identifying medicines, in particular to a method for identifying nimodipine tablets. Background technique [0002] Nimodipine Tablets can selectively expand cerebral blood vessels, have both neurological and psychopharmacological activities, and have a relatively high selective expansion effect on coronary arteries. The improvement of blood circulation in the recovery period of vascular disease also has a good effect in the treatment of mild and moderate vascular dementia. Clinically, it is mainly used for subarachnoid hemorrhage, migraine, stroke, sudden deafness, mild to moderate hypertension and other diseases. It is now the drug of choice for the prevention and treatment of cerebrovascular diseases and senile dementia. The existing nimodipine tablet identification method has problems such as low precision, high repeatability, and prone to deviation, and cannot control the quality of the product well. Content...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 顾建光
Owner 顾建光
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