Internal tectorial membrane made by electrospinning for duodenum

A technology of duodenum and inner covering, which is applied in the device of human tubular structure, medical science, non-surgical orthopaedic surgery, etc., can solve the problem of no embodiment and the like

Active Publication Date: 2012-11-21
万平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Invention patent of the prior art "A preparation method of air-permeable and water-impermeable polyurethane nanofiber membrane" (application date December 5, 2011, publication date 2012 June February 27), it is an electrospinning method with multiple nozzles. Although it is mentioned that it can be applied to "biological tissue engineering", there are no related examples, let alone the specific details of using electrospinning to make the duodenal inner membrane. Example

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] For medical polylactic acid, the solvent is a mixed solvent of chloroform / ethanol, the volume ratio is 45 / 55 (v / v), and the concentration is 5wt%; for medical polyurethane, the solvent is dimethyl sulfoxide, and the concentration is 9wt%. The voltage is 16KV, the propulsion speed is 0.4ml / h, the receiving distance is 14cm, and the inner diameter of the pinhole is 0.4mm. In a fume hood at room temperature of 23°C, the tubular part was electrospun with a medical polyurethane solution, and the ampulla was electrospun with a medical polylactic acid solution.

Embodiment 2

[0041] For medical polylactic acid, the solvent is a mixed solvent of chloroform / ethanol, the volume ratio is 50 / 50 (v / v), and the concentration is 6wt%; for medical polyurethane, the solvent is dimethyl sulfoxide, and the concentration is 7wt%. The voltage is 18KV, the propulsion speed is 0.5ml / h, the receiving distance is 16cm, and the inner diameter of the pinhole is 0.3mm. At room temperature of 25°C, in a fume hood, the tubular part was electrospun with a medical polyurethane solution, and the ampulla was electrospun with a medical polylactic acid solution.

Embodiment 3

[0043] For medical polylactic acid, the solvent is a mixed solvent of chloroform / ethanol, the volume ratio is 45 / 55 (v / v), and the concentration is 5wt%; for medical polyurethane, the solvent is dimethyl sulfoxide, 9wt%. The voltage is 19KV, the propulsion speed is 0.4ml / h, the receiving distance is 14cm, and the inner diameter of the pinhole is 0.3mm. Medical polyurethane, the solvent is N-N-dimethylacetamide, the concentration is 20wt%, the voltage is 19KV, the advancing speed is 2.8ml / h, the receiving distance is 20cm, and the inner diameter of the pinhole is 0.3mm. The room temperature is 24°C, in a fume hood, the inner layer is electrospun with a medical polylactic acid solution, and the outer layer is electrospun with a medical polyurethane solution.

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Abstract

The invention provides an internal tectorial membrane for duodenum, and relates to a built-in degradable medical instrument in a digestive tract. The internal tectorial membrane can be made of biocompatible materials by electrospinning. The internal tectorial membrane is placed in the duodenum of a patient, not only can stop food from contacting with the intestinal mucosae of the patient during dissection, but also avoids affecting functions of cells of the intestinal mucosae physiologically, can be obtained by hybrid electrospinning or / and multi-layered electrospinning or / and core-shell electrospinning or / and dry-method electrospinning, and can be manufactured into a medical instrument which can reduce injury, prevent dropping, avoid being removed and restrain bounce and can be used for treating diabetes mellitus and adiposis.

Description

technical field [0001] The invention relates to a degradable medical device built in the digestive tract, in particular to a duodenal inner covering film for treating diabetes and obesity. [0002] Background technique [0003] In March 2011, at the 2nd International Conference on Interventional Treatment of Type 2 Diabetes held in New York, USA, the International Diabetes Federation (IDF) issued a statement for the first time, arguing that gastric bypass surgery can be used to treat obese patients with Type 2 diabetes and reduce the risk of diabetes. The occurrence and development of chronic complications. (Chinese Medical Science, 2011, 1(22): 1-2) This operation can also significantly improve patients' complications such as hypertension, obesity, and blood lipid disorders. (Chinese Medical Science, 2011,1(21):3-5) [0004] However, gastric bypass surgery has clinical risks, such as death, intestinal obstruction, anastomotic leakage, pulmonary embolism, deep vein thromb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00A61F5/00A61L31/14
CPCA61F5/0013A61F2002/045A61F2/04A61F2230/0067A61F2240/001A61F2250/0039A61F5/0076
Inventor 万平
Owner 万平
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