Application of equol-based BKCa channel activation

A technology of equol and channels, which is applied in the application field based on the activation of BKCa channels based on equol, can solve the problems of high experimental technology and condition requirements, large trauma, etc., and achieve the effect of increasing cerebral blood flow and strong cerebral blood vessel selectivity Effect

Active Publication Date: 2014-11-05
XI AN JIAOTONG UNIV
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Problems solved by technology

The most accurate and reliable measurement method is direct measurement through aortic catheterization...

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  • Application of equol-based BKCa channel activation
  • Application of equol-based BKCa channel activation
  • Application of equol-based BKCa channel activation

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Experimental program
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Embodiment Construction

[0042] The invention adopts rat focal cerebral ischemia-reperfusion model, tail cuff method to measure rat blood pressure, laser Doppler flowmeter to observe brain parenchyma and pia mater blood flow, isolated blood vessel myotonography and patch clamp Technology, to verify the anti-ischemic effect of equol, the results show that equol activates BK Ca The channel β1 subunit expands blood vessels, increases cerebral blood flow, and protects ischemia-reperfusion brain tissue, and can be used in the preparation of related drugs. The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0043] 1. Protective effect of equol on focal cerebral ischemia-reperfusion injury in rats

[0044] 1. Material

[0045] 1.1 Instrument GPS type bipolar coagulator (Shanghai Medical Laser Instrument Factory), electric heating three water tank (SHHW21.420, Tianjin Test Instr...

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Abstract

The invention discloses an application of equol-based BKCa channel activation. Pharmaceutical activity of equol is detected on the basis of applying a rat focal cerebral ischemia reperfusion model, a tail-cuff method to measure rat blood pressure, a Laser Doppler Flowmetry to observe brain parenchyma and pia mater blood flow, an in-vitro vascular muscle tension tracing and a patch clamp technology, and results show that the equol, through activating beta1 subunit of BKCa channel, can dilate blood vessels, increase cerebral blood flow and protect ischemic reperfusion brain tissue, is beneficial for prevention and treatment of ischemia brain stroke, and can be used for preparation of related medicaments.

Description

technical field [0001] The invention belongs to the technical field of K+ channel stimulation and relates to the activation of BK based on equol Ca channel application. Background technique [0002] K+ channels play an important role in maintaining the membrane potential of arterial smooth muscle cells and regulating vascular tone. Depending on the gating properties, the K of vascular smooth muscle + Channels can be divided into at least 4 types, namely: voltage-gated K + channel (voltage-gated K + channel, Kv channel), inward rectification K + channel (inward rectifier K + channel, Kir channel), ATP sensitivity K + channel (ATP-sensitive K + channel, K ATP channels) and calcium-activated K + channel (Ca 2+ -activated K + channel, K Ca aisle). [0003] According to the difference in single-channel conductance size and pharmacological properties, K Ca Channels can be further divided into three subclasses: large conductance calcium-activated K + channel (big...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P25/00A61P9/10
Inventor 邓秀玲于玮王燕
Owner XI AN JIAOTONG UNIV
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