Biological membrane which promotes healing and preparation method thereof

A technology of biofilm and chitosan derivatives, applied in medical science, bandages, absorbent pads, etc., can solve the problems of less absorption of wound exudate, poor mechanical properties, and use restrictions, and achieve strong absorption and mechanical properties The effect of improving and avoiding potential harm

Inactive Publication Date: 2012-12-12
上海白衣缘生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gel preparations of chitosan or its derivatives have the disadvantages of absorbing less wound exudate and difficulty in changing dressings.
However, pure chitosan or its derivative film, sponge or non-woven fabric preparations are limited in use due to poor mechanical properties, melt

Method used

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  • Biological membrane which promotes healing and preparation method thereof
  • Biological membrane which promotes healing and preparation method thereof
  • Biological membrane which promotes healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of Healing Biofilms

[0040] Carboxymethyl chitosan was dissolved in phosphate buffer to make a 5% (W / V) glue solution. Add sesame oil so that the concentration of sesame oil is 1.5% (W / V). Add calcium chloride so that its concentration in the blend is 0.8%. well mixed. Pour it into a stainless steel pan with a thickness of 5mm, and dry it at 40°C for 10 hours in a hot air circulation box to form a film. The film is cut into an appropriate size, packaged in an inner packaging bag, and sterilized by irradiation with 30Kgy of cobalt 60 to obtain a healing-promoting biofilm.

Embodiment 2

[0041] Example 2: Preparation of Healing Biofilms

[0042]Dissolve carboxymethyl chitosan in phosphate buffer to make 3% (W / V) glue. Add sesame oil so that the concentration of sesame oil is 2.5% (W / V). Add zinc gluconate so that its concentration in the blend is 0.5%. well mixed. Pour it into a stainless steel pan with a thickness of 7mm, and dry it at 37°C for 16 hours in a hot air circulation box to form a film. The film is cut into an appropriate size, packaged in an inner packaging bag, and sterilized by irradiation with 25Kgy of cobalt 60 to obtain a healing-promoting biofilm.

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Abstract

The invention discloses a biological membrane which promotes healing and a preparation method thereof. The biological membrane which promotes healing is prepared by mixing chitosan derivative solution and sesame oil for ionic crosslink and drying the mixture to form membrane. The membrane has a certain flexibility and strength and integral gel can be formed after the membrane absorbs exudates. Adhesion with wound surface can be avoided, thus medicine changing is convenient and no secondary injury is caused. In addition, the membrane has the advantages of moist keeping, antibacterial action, scars reducing and the like. The membrane has obvious curative effect of promoting wound to heal and is applicable to curing surgical wound, bruise, burn, donor site, bedsore, diabetic ulcer and other wound surfaces which are difficult to heal.

Description

technical field [0001] The invention relates to a biofilm for promoting healing, in particular to a biofilm for promoting wound healing prepared by taking chitosan derivatives and sesame oil as main raw materials, and belongs to the field of biomedical materials. Background technique [0002] Trauma is the damage of normal skin (tissue) caused by external injury factors such as surgery, external force, heat, electric current, chemical substances, low temperature, and internal factors such as local blood supply disturbance. Common traumas include surgical incisions, abrasions, burns, donor sites, decubitus ulcers, vascular ulcers of lower extremities, diabetic ulcers, and other difficult-to-heal wounds. The formation and existence of trauma will have a major impact on the local and even whole body functions of the body. In order to accelerate the healing of the wound and reduce the infection of the wound surface, dressings are generally used to cover and protect the wound. ...

Claims

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Application Information

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IPC IPC(8): A61L15/40A61L15/28A61L15/42
Inventor 韩韦红徐雪英王园园
Owner 上海白衣缘生物工程有限公司
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