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A traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases

A technology that replaces antibiotics and the digestive tract, applied in the field of veterinary medicine, can solve problems such as increased difficulty in treatment, health hazards of humans, animals and plants, and achieve the effects of accurate dosage, stable preparation, and controllable quality

Inactive Publication Date: 2014-10-15
CHONGQING ACAD OF ANIMAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of drug-resistant strains and the transfer of drug resistance have made the treatment of bacterial diseases more difficult. Many pathogens have a certain resistance to most drugs. Even an effective drug will be effective after a period of time. It will also be significantly reduced. The problem of bacterial resistance to antibacterial drugs is becoming more and more serious. The problem has become a hot spot of global concern, and bacterial resistance has also become a public health problem of global concern

Method used

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  • A traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases
  • A traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases
  • A traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases

Examples

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Effect test

Embodiment 1

[0016] Example 1 Oral preparation of traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial disease

[0017] Formula 1: a traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases. It consists of the following components in parts by weight: 10 parts of cat's claw, 10 parts of sophora flavescens, 1 part of shredded tobacco, 5 parts of chrysanthemum, and horseshoe incense 30 parts, 40 parts of coptis, and 40 parts of Houttuynia cordata.

[0018] Formula 2: a traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases. It consists of the following components in parts by weight: 25 parts of cat's claw, 25 parts of sophora flavescens, 5 parts of shredded tobacco, 10 parts of chrysanthemum, and horseshoe incense 20 parts, 10 parts of Coptidis Rhizome, 5 parts of Houttuy...

Embodiment 2

[0021] Example 2 Bacteriostasis test of traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial disease

[0022] The in vitro antibacterial test in this study showed that the combined application of cat's claw, flavescens, shredded tobacco, chrysanthemum, horseshoe incense, coptis, and Houttuynia cordata can improve the in vitro antibacterial activity of the drug. Taking 36 strains of drug-resistant salmonella from porcine as the research object, taking penicillin, streptomycin, gentamycin, and neomycin as controls, the active ingredients were extracted with water extraction method in formula 1 in Example 1, and the antibacterial test was carried out.

[0023] The water extraction method is specifically: after pulverizing each component of formula 1, add deionized water equivalent to 8 times the volume (5-10 times) of the volume of the traditional Chinese medicine composition of formula 1, and extract at 90°C f...

Embodiment 3

[0030] Example 3 The traditional Chinese medicine composition that can replace antibiotics to prevent and treat piglet digestive tract bacterial diseases to prevent piglet paratyphoid fever

[0031] Select 300 piglets, and take preparation 2 orally at 0.1-2g / kg body weight, twice a day, for 2-3 consecutive days, and then for 2-3 consecutive days after an interval of 2-3 days, repeating the cycle, you can prevent paratyphoid fever in piglets, and the prevention rate higher than 95%.

[0032] Another 300 piglets were selected, and the preparation 3 was orally administered at 3-5g / kg body weight, 3 times a day, for 2-10 consecutive days, to treat paratyphoid fever in piglets, and the cure rate was higher than 90%.

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Abstract

The invention belongs to the field of animal medicine, and relates to a veterinary drug, particularly to a traditional Chinese drug composition capable of replacing antibiotic to prevent and treat piglet digestive tract bacterial diseases. The traditional Chinese drug composition comprises the following components, by weight, 10-25 parts of catclaw buttercup root tuber, 10-25 parts of lightyellow sophora root, 1-5 parts of tobacco shred, 5-10 parts of chrysanthemum, 20-30 parts of saruma henryi, 10-40 parts of coptis chinensis, and 5-40 parts of heartleaf houttuynia herb. The traditional Chinese drug composition of the present invention has the following advantages that: (1) a new compound traditional Chinese drug preparation capable of replacing the antibiotic to prevent and treat piglet digestive tract bacterial diseases is developed for veterinary clinic; (2) the formulation is reasonable, and the selected drugs are screened by carrying out systemic combination drug sensitive tests based on in vitro drug sensitive tests of 500 pig digestive tract separation pathogens; (3) the traditional Chinese drug composition has characteristics of safety, efficiency, low toxicity, low residue, and easy use; and (4) the production process is simple, the preparation is stable, the dose is accurate, and the quality is controllable.

Description

technical field [0001] The invention belongs to the field of animal medicine, in particular to veterinary medicine. Background technique [0002] Piglet digestive tract bacterial disease is one of the frequent bacterial infectious diseases in large-scale farms, and it is also one of the infectious diseases that are more harmful to large-scale pig production. In order to minimize the losses caused by piglet bacterial gastrointestinal diseases, the most effective measures are the prevention before the onset and the treatment after the onset. At present, the main measures are the application of chemical drugs or antibiotics. [0003] Bacterial pathogens such as Salmonella and Escherichia coli that cause infectious diseases in the digestive system of piglets. The outbreak of these diseases reduces feed efficiency, affects the growth rate of piglets and the overall uniformity of the pig herd, and even leads to higher mortality rates. The cost of disease diagnosis and treatment h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61P31/04
Inventor 杨金龙刘作华黄勇付利芝杨飞云翟少钦沈克飞李大军
Owner CHONGQING ACAD OF ANIMAL SCI
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