Application of Houttuynoid B in helicobacter pylori resistant medicament
A technology for anti-helicobacter pylori and drugs, which is applied in the field of preparation of anti-helicobacter pylori drugs, can solve problems such as indigestion and the destruction of bacterial flora in the digestive tract, and achieve the effect of strong inhibitory activity and outstanding substantive characteristics
Inactive Publication Date: 2013-08-28
北京耀伦生物科技有限公司
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AI Technical Summary
Problems solved by technology
The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora
Method used
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Experimental program
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Effect test
Embodiment 1
[0012] Embodiment 1: the preparation of compound Houttuynoid B tablet involved in the present invention:
[0013] Take 20 grams of compound Houttuynoid B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.
Embodiment 2
[0014] Embodiment 2: the preparation of compound Houttuynoid B capsules involved in the present invention:
[0015] Take 20 grams of compound Houttuynoid B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0016] The following pharmacodynamic experiments will further illustrate its drug activity.
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In-vitro activity experiments show that Houttuynoid B has strong helicobacter pylori (Hp) resistant activity. The Houttuynoid B can be applied to treatment of diseases such as acute and chronic gastritis and gastric and duodenal ulcer and preparation of medicaments for treating the acute and chronic gastritis and the gastric and duodenal ulcer. The invention discloses the application of the Houttuynoid B in preparation of the Hp resistant medicaments for the first time, the skeleton type belongs to a brand-new skeleton type, the Houttuynoid B has unexpected strong inhibiting activity on the Hp, the probability of giving any revelation by other compounds does not exist, and the Houttuynoid B has predominant substantial characteristics and obviously makes a remarkable progress on prevention and treatment of Hp infection.
Description
technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to the application of Houttuynoid B in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of proton pump inhibitor (PPI) plus two antibiotics (choose two from clarithromycin, amoxicillin, tetracycline, metronidazole, etc.). The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; ...
Claims
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IPC IPC(8): A61K31/7048A61P31/04A61P1/04
Inventor 黄晨吴俊艺吴俊华
Owner 北京耀伦生物科技有限公司