Application of vardenafil hydrochloride tables in preparation of medicine for treating pulmonary arterial hypertension

A technology for vardenafil hydrochloride and pulmonary arterial hypertension, which is applied in a new application. The application field of vardenafil hydrochloride tablets in the preparation of drugs for treating pulmonary arterial hypertension can solve the problems of poor pulmonary arterial hypertension drugs and other problems, and achieve a reduction in average Effects of pulmonary arterial pressure and pulmonary vascular resistance, improvement of exercise tolerance and hemodynamic parameters, improvement of cardiac output and cardiac function classification

Inactive Publication Date: 2013-03-06
荆志成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide the application of vardenafil hydrochloride sheet in the preparation treatment pulmonary hypertension medicine, the application of described this vardenafil hydrochloride sheet in the preparation treatment of pulmonary hypertension disease will solve the problem in the prior art Technical Problems of Ineffective Drugs in the Treatment of Pulmonary Arterial Hypertension

Method used

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  • Application of vardenafil hydrochloride tables in preparation of medicine for treating pulmonary arterial hypertension
  • Application of vardenafil hydrochloride tables in preparation of medicine for treating pulmonary arterial hypertension
  • Application of vardenafil hydrochloride tables in preparation of medicine for treating pulmonary arterial hypertension

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Embodiment 1

[0012] 1. Objects and methods

[0013] 1.1 Selected objects

[0014] Patients with pulmonary arterial hypertension of WHO cardiac function class II and III, with a 6-minute walking distance (6-minute walking distance, 6MWD) between 150 and 550 meters, were selected and followed up for 24 weeks. Eligible subjects include: idiopathic pulmonary arterial hypertension (IPAH), connective tissue-associated pulmonary hypertension (CTD-PAH, including systemic lupus erythematosus, scleroderma, mixed ground tissue disease), repaired congenital heart disease-associated pulmonary hypertension (via 3 years after skin or surgical repair).

[0015] 1.2 Inclusion and exclusion criteria

[0016] Patients with IPAH, CHD-PAH and CTD-PAH who received oral vardenafil hydrochloride tablets and completed two right heart catheterizations at baseline and 12-week follow-up. The diagnosis of pulmonary arterial hypertension is confirmed according to the results of right heart catheterization: the mean ...

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Abstract

The invention discloses an application of vardenafil hydrochloride tables in preparation of a medicine for treating pulmonary arterial hypertension, belonging to the field of medicinal chemistry. According to the invention, vardenafil hydrochloride tables are proved to be capable of increasing 6-minute walking distance, reducing average pulmonary arterial pressure and pulmonary vessel resistance, improving cardiac output and cardiac functional grading, and decreasing the occurrence rate of clinical worsening for the patient with pulmonary arterial hypertension via a randomized clinical trial, a double-blind clinical trial and a placebo control clinical trial. The exercise tolerance and the haemodynamic parameters of the patient with pulmonary arterial hypertension can be improved by taking 5 mg of vardenafil hydrochloride tables twice every day; and moreover, the vardenafil hydrochloride tables are good in safety and tolerance.

Description

Technical field: [0001] The invention relates to the field of medicinal chemistry, in particular to a new application of vardenafil hydrochloride tablets, in particular to the application of vardenafil hydrochloride tablets in the preparation of drugs for treating pulmonary hypertension. Background technique: [0002] Vardenafil Hydrochloride Tablets, trade name: Levitra, is a drug approved by the US FDA for the treatment of male erectile dysfunction. The main ingredient is vardenafil hydrochloride, chemical name: 2-[2-ethoxy-5-4-(ethyl-piperazine-1-sulfonyl)-phenyl]-5-methyl-7- Propyl-3H-imidazol[5,1-f]-[1,2,4]terazin-4-one monohydrochloride, light orange to dark orange film-coated tablet. Vardenafil hydrochloride increases the release of local endogenous nitric oxide in the cavernous body under sexual stimulation by inhibiting the phosphodiesterase type 5 (PDE5) that degrades cGMP in the cavernous body of the human penis, thereby enhancing the natural response to sexual s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61P9/12A61P11/00
Inventor 荆志成蒋鑫张锐袁平韩志岩何晶
Owner 荆志成
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