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Application of salvianolic acid B salt in preparing medicament for inhibiting hepatic stellate cell migration

A technology of hepatic stellate cells and salvianolic acid, which is applied in the application field of medicine, and can solve the problems such as no relevant reports of salvianolic acid B salt

Inactive Publication Date: 2013-03-27
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the role of salvianolic acid B salt in inhibiting the migration of hepatic stellate cells

Method used

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  • Application of salvianolic acid B salt in preparing medicament for inhibiting hepatic stellate cell migration
  • Application of salvianolic acid B salt in preparing medicament for inhibiting hepatic stellate cell migration
  • Application of salvianolic acid B salt in preparing medicament for inhibiting hepatic stellate cell migration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The salvianolic acid B salt of the present invention is made into tablets according to methods known to those skilled in the art. Salvianolic acid B salt tablets, each containing 100mg of salvianolic acid B salt, 100mg of microcrystalline cellulose, 40mg of micropowder silica gel, 20mg of lactose, and 1.0mg of magnesium stearate. Usage: 1 tablet each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 2

[0068] Salvianolic acid B salt of the present invention is made into capsules according to methods known to those skilled in the art. Salvianolic acid B salt capsules, each containing 100mg of salvianolic acid B salt. Usage: 1 capsule each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

Embodiment 3

[0070] Salvianolic acid B salt of the present invention is prepared into granules according to methods known to those skilled in the art. Salvianolic acid B salt granules, each bag contains 100mg of salvianolic acid B salt, 100mg of microcrystalline cellulose, 40mg of micropowder silica gel, 1.0mg of stearic acid, and 20mg of lactose. Usage: 1 bag each time, 2-3 times a day, 5-6 days a week, every 3-4 weeks as a course of treatment.

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Abstract

The invention discloses application of salvianolic acid B salt in preparing a medicament for inhibiting hepatic stellate cell migration. A screening platform of PDGF (platelet derived growth factor) induced human hepatic stellate cell strain (LX-2) migration is designed, and the fact that the salvianolic acid B salts with the concentrations of 10<-4> and 10<-7>mol / L both can be used for inhibiting migration of a PDGF induced hepatic stellate cell (HSC) is discovered.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to the application of salvianolic acid B salt in the preparation of medicines for inhibiting the migration of hepatic stellate cells. Background technique [0002] Salvianolic acid B salt, also known as salvianolic acid B or shikonic acid B, is extracted from the natural plant Salvia miltiorrhiza. Lowering blood pressure, lowering blood sugar, anti-inflammatory, anti-allergic, anti-oxidation, anti-infection, used to treat cervical erosion, skin diseases and acne, etc. It has important pharmacological effects on the heart, brain, liver and other organs. [0003] Various liver diseases, such as chronic hepatitis B, chronic hepatitis C, alcoholic or non-alcoholic fatty liver disease, autoimmune liver disease, drug-induced liver disease, chronic schistosomiasis, and some metabolic or congenital chronic liver diseases can be passed Liver fibrosis progresses to c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P1/16
Inventor 徐列明张展
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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